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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0006393
http://purl.obolibrary.org/obo/HINO_0006393
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|---|---|
| Preferred Name | PPBSF is a complex of IL7 and HGFbeta |
| Definitions |
The pre-pro-B cell growth-stimulating factor (PPBSF) is a self-assembling complex of IL7 and a variant beta-chain of hepatocyte growth factor (HGFbeta) (Lai & Goldschneider 2001). This 55 kDa heterodimer, unlike monomeric IL7, selectively stimulates proliferation and differentiation of pre-pro-B cells in a long-term bone marrow culture system and up-regulates IL7R alpha chain expression on pre-pro-B cell surface. It has been postulated that PPBSF is the active form of IL7 that normally induces IL7R-lo pre-pro-B cells to proliferate and differentiate into IL7R-hi pro-B cells, which then proliferate and differentiate into pre-B-cells on stimulation with monomeric IL7 (Wei et al. 2002).
Authored: Ray, KP, 2010-05-17
Edited: Jupe, S, 2011-05-06
Reviewed: Puck, J, 2011-11-03
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
PPBSF is a complex of IL7 and HGFbeta
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| comment |
The pre-pro-B cell growth-stimulating factor (PPBSF) is a self-assembling complex of IL7 and a variant beta-chain of hepatocyte growth factor (HGFbeta) (Lai & Goldschneider 2001). This 55 kDa heterodimer, unlike monomeric IL7, selectively stimulates proliferation and differentiation of pre-pro-B cells in a long-term bone marrow culture system and up-regulates IL7R alpha chain expression on pre-pro-B cell surface. It has been postulated that PPBSF is the active form of IL7 that normally induces IL7R-lo pre-pro-B cells to proliferate and differentiate into IL7R-hi pro-B cells, which then proliferate and differentiate into pre-B-cells on stimulation with monomeric IL7 (Wei et al. 2002).
Authored: Ray, KP, 2010-05-17
Edited: Jupe, S, 2011-05-06
Reviewed: Puck, J, 2011-11-03
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| prefLabel |
PPBSF is a complex of IL7 and HGFbeta
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| definition source |
Reactome, http://www.reactome.org
Pubmed11564764
Pubmed12184921
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| prefixIRI |
HINO:0006393
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| seeAlso |
Reactome Database ID Release 431266684
ReactomeREACT_116110
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| has output |
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