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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0006379
http://purl.obolibrary.org/obo/HINO_0006379
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| Preferred Name | STAT1/3 dimers translocate to the nucleus |
| Definitions |
Authored: Ray, K, 2010-12-13
Edited: Jupe, S, 2010-12-10
In untreated cells both STAT1 and STAT3 are distributed diffusely in the cytoplasm and the nucleus. A few minutes after IL-6 treatment both are preferentially located in the nucleus. This translocation is transient; after 2 h the distribution is comparable to that of untreated cells (Zhang et al. 1995). The mechanism by which STATs enter the nucleus is likely to be mediated by importins via nuclear pore complexes (NPCs) (Reich & Liu, 2006).
Reviewed: Rose-John, S, 2011-02-11
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
STAT1/3 dimers translocate to the nucleus
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| comment |
Authored: Ray, K, 2010-12-13
Edited: Jupe, S, 2010-12-10
In untreated cells both STAT1 and STAT3 are distributed diffusely in the cytoplasm and the nucleus. A few minutes after IL-6 treatment both are preferentially located in the nucleus. This translocation is transient; after 2 h the distribution is comparable to that of untreated cells (Zhang et al. 1995). The mechanism by which STATs enter the nucleus is likely to be mediated by importins via nuclear pore complexes (NPCs) (Reich & Liu, 2006).
Reviewed: Rose-John, S, 2011-02-11
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| prefLabel |
STAT1/3 dimers translocate to the nucleus
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| definition source |
Reactome, http://www.reactome.org
Pubmed16868551
Pubmed7701321
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| prefixIRI |
HINO:0006379
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| seeAlso |
Reactome Database ID Release 431112587
ReactomeREACT_27303
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| has output |
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