loading...| Preferred Name | Serine phosphorylation of STATs | |
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has a Stoichiometric coefficient of 2 Authored: Ray, K, 2010-12-13 Edited: Jupe, S, 2010-12-10 In addition to tyrosine phosphorylation, STAT1 and STAT3 undergo serine phosphorylation at serine-727, contributing to maximal transcriptional activity (Wen & Darnell 1997, Shen et al. 2004). Though several candidates exist including Protein kinase C delta (Jain et al. 1999), the kinase responsible for IL-6 regulation of Stat serine phosphorylation has yet to be identified (Jain et al. 1999, Abe et al. 2001, Chung et al. 1997) and the significance of serine phosphorylation is unclear (Decker & Kovarik 2000); STAT3 modifed by serine phosphorylation augments oxidative phosphorylation in mitochondria and supported cellular transformation by oncogenic Ras (Reich 2009). Reviewed: Rose-John, S, 2011-02-11 |
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http://purl.obolibrary.org/obo/HINO_0006375 |
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has a Stoichiometric coefficient of 2 Authored: Ray, K, 2010-12-13 Edited: Jupe, S, 2010-12-10 In addition to tyrosine phosphorylation, STAT1 and STAT3 undergo serine phosphorylation at serine-727, contributing to maximal transcriptional activity (Wen & Darnell 1997, Shen et al. 2004). Though several candidates exist including Protein kinase C delta (Jain et al. 1999), the kinase responsible for IL-6 regulation of Stat serine phosphorylation has yet to be identified (Jain et al. 1999, Abe et al. 2001, Chung et al. 1997) and the significance of serine phosphorylation is unclear (Decker & Kovarik 2000); STAT3 modifed by serine phosphorylation augments oxidative phosphorylation in mitochondria and supported cellular transformation by oncogenic Ras (Reich 2009). Reviewed: Rose-John, S, 2011-02-11 |
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Reactome, http://www.reactome.org Pubmed19797267 Pubmed14673173 Pubmed9343414 Pubmed11429693 Pubmed9153303 Pubmed10851062 Pubmed10446219 |
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Serine phosphorylation of STATs |
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HINO:0006375 |
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Serine phosphorylation of STATs |
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ReactomeREACT_27262 Reactome Database ID Release 431112727 |
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