Human Interaction Network Ontology

Last uploaded: June 27, 2014
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Id http://purl.obolibrary.org/obo/HINO_0006337
http://purl.obolibrary.org/obo/HINO_0006337
Preferred Name

SOCS binding to JAK2
Definitions
Authored: Jupe, S, 2010-10-14 Reviewed: Waters, MJ, 2011-06-23 SOCS1 can bind JAK2 and inhibit JAK kinase activity (Yasukawa et al. 1999). SOCS3 also inhibits JAK2 kinase activity (Sasaki et al. 1999) while all of SOCS1 -3 and CIS inhibit GHR signaling (Ram & Waxman 1999, Nicholson et al. 2000). This is not thought to be simply the outcome of binding competition between SOCS and STAT5, but a direct action of SOCS on JAK2 (Ram & Waxman 1999). Although SOCS are known to be ubiquitin ligases (Kamura et al. 2004), ubiquitin ligase activity on JAK2 or GHR has not been demonstrated and a role for SOCS in the ubiquitination of these proteins has been questioned (Flores-Morales et al. 2006). An alternative model suggested by the observation that SOCS3 strongly inhibits JAK2 only in the presence of GHR proposes that SOCS serve as an inhibitory 'bridge' by binding simultaneously to GHR and JAK2 (Ram & Waxman 1999). Edited: Jupe, S, 2011-06-10 Reviewed: Herington, AC, 2011-06-13
Type http://www.w3.org/2002/07/owl#Class

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SOCS binding to JAK2
comment
Authored: Jupe, S, 2010-10-14
Reviewed: Waters, MJ, 2011-06-23
SOCS1 can bind JAK2 and inhibit JAK kinase activity (Yasukawa et al. 1999). SOCS3 also inhibits JAK2 kinase activity (Sasaki et al. 1999) while all of SOCS1 -3 and CIS inhibit GHR signaling (Ram & Waxman 1999, Nicholson et al. 2000). This is not thought to be simply the outcome of binding competition between SOCS and STAT5, but a direct action of SOCS on JAK2 (Ram & Waxman 1999). Although SOCS are known to be ubiquitin ligases (Kamura et al. 2004), ubiquitin ligase activity on JAK2 or GHR has not been demonstrated and a role for SOCS in the ubiquitination of these proteins has been questioned (Flores-Morales et al. 2006). An alternative model suggested by the observation that SOCS3 strongly inhibits JAK2 only in the presence of GHR proposes that SOCS serve as an inhibitory 'bridge' by binding simultaneously to GHR and JAK2 (Ram & Waxman 1999).
Edited: Jupe, S, 2011-06-10
Reviewed: Herington, AC, 2011-06-13
prefLabel
SOCS binding to JAK2
definition source
Pubmed10421843
Pubmed10585430
Pubmed10829066
Reactome, http://www.reactome.org
Pubmed15601820
Pubmed16037128
Pubmed10064597
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HINO:0006337
seeAlso
ReactomeREACT_111198
Reactome Database ID Release 431168813
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