loading...| Preferred Name | Lyn activates ERK | |
| Synonyms |
|
|
| Definitions |
has a Stoichiometric coefficient of 4 Authored: Jupe, S, 2010-10-14 The activation of Lyn by GHR is thought to indirectly activate ERK. Mutations of GHR predicted to disable a conformational change brought about by GH binding impaired ERK signaling but not JAK2/STAT5 signaling. ERK signaling was demonstrated to involve the Src family kinase Lyn (Rowlinson et al. 2008) and suggested to involve Src kinase dependent activation of Phospholipase C gamma and thereby Ras, similar to a mechanism proposed by Bivona et al. (2003). ERK activation mechanisms involving Src kinases and PLCgamma have been reported for the erythropoietin, thrombopoietin and prolactin receptors (Brooks & Waters 2010). Reviewed: Waters, MJ, 2011-06-23 Edited: Jupe, S, 2011-06-10 Reviewed: Herington, AC, 2011-06-13 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0006322 |
|
| comment |
has a Stoichiometric coefficient of 4 Authored: Jupe, S, 2010-10-14 The activation of Lyn by GHR is thought to indirectly activate ERK. Mutations of GHR predicted to disable a conformational change brought about by GH binding impaired ERK signaling but not JAK2/STAT5 signaling. ERK signaling was demonstrated to involve the Src family kinase Lyn (Rowlinson et al. 2008) and suggested to involve Src kinase dependent activation of Phospholipase C gamma and thereby Ras, similar to a mechanism proposed by Bivona et al. (2003). ERK activation mechanisms involving Src kinases and PLCgamma have been reported for the erythropoietin, thrombopoietin and prolactin receptors (Brooks & Waters 2010). Reviewed: Waters, MJ, 2011-06-23 Edited: Jupe, S, 2011-06-10 Reviewed: Herington, AC, 2011-06-13 |
|
| definition source |
Pubmed12845332 Pubmed20664532 Reactome, http://www.reactome.org Pubmed18488018 |
|
| has input | ||
| has output | ||
| label |
Lyn activates ERK |
|
| prefixIRI |
HINO:0006322 |
|
| prefLabel |
Lyn activates ERK |
|
| seeAlso |
Reactome Database ID Release 431168459 EC Number: 2.7.10.2 ReactomeREACT_111235 |
|
| subClassOf |