Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel

Synonyms
Definitions

Authored: Le Novere, N, Jassal, B, 2004-03-31 12:22:05 has a Stoichiometric coefficient of 4 The IP3 receptor (IP3R) is an IP3-gated calcium channel. It is a large, homotetrameric protein, similar to other calcium channel proteins such as ryanodine. The four subunits form a 'four-leafed clover' structure arranged around the central calcium channel. Binding of ligands such as IP3 results in conformational changes in the receptor's structure that leads to channel opening. Reviewed: Gillespie, ME, 2009-06-02 00:56:21 Edited: Jassal, B, 2006-10-10 09:20:18

ID

http://purl.obolibrary.org/obo/HINO_0004813

comment

Authored: Le Novere, N, Jassal, B, 2004-03-31 12:22:05

has a Stoichiometric coefficient of 4

The IP3 receptor (IP3R) is an IP3-gated calcium channel. It is a large, homotetrameric protein, similar to other calcium channel proteins such as ryanodine. The four subunits form a 'four-leafed clover' structure arranged around the central calcium channel. Binding of ligands such as IP3 results in conformational changes in the receptor's structure that leads to channel opening.

Reviewed: Gillespie, ME, 2009-06-02 00:56:21

Edited: Jassal, B, 2006-10-10 09:20:18

definition source

Reactome, http://www.reactome.org

has input

http://purl.obolibrary.org/obo/HINO_0025446

http://purl.obolibrary.org/obo/CHEBI_16595

has output

http://purl.obolibrary.org/obo/HINO_0025447

label

IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel

prefixIRI

HINO:0004813

prefLabel

IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel

seeAlso

ReactomeREACT_12008

Reactome Database ID Release 43169680

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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