loading...| Preferred Name |
Transient dissociation of 14-3-3 upon Ras binding |
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| Definitions |
Reviewed: Heldin, CH, 2008-02-12 09:44:02 Edited: Schmidt, EE, 0000-00-00 00:00:00 Activated p21ras (the GTP-bound form) is associated with the plasma membrane. Inactive Raf-1 is associated in the cytoplasm with 14-3-3. 14-3-3 binds to Raf-1 via the Ser259 phosphorylation site (S1). This interaction stabilises the inactive conformation of Raf-1 in which the Ras-binding Cysteine-rich domain (CRD) is obscured. The Raf-1 molecule contains an additional p21ras-binding domain (RBD), a second serine phosphorylation site at S621 (S2) and two tyrosine phosphorylation sites (at 340, Y1 and 341, Y2).<br>Raf-1 binds activated p21ras via the RBD. This displaces 14-3-3 from Ser259 and unmasks the CRD. Authored: Charalambous, M, 2005-01-07 11:17:43 |
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http://purl.obolibrary.org/obo/HINO_0004539 |
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| comment |
Reviewed: Heldin, CH, 2008-02-12 09:44:02 Edited: Schmidt, EE, 0000-00-00 00:00:00 Activated p21ras (the GTP-bound form) is associated with the plasma membrane. Inactive Raf-1 is associated in the cytoplasm with 14-3-3. 14-3-3 binds to Raf-1 via the Ser259 phosphorylation site (S1). This interaction stabilises the inactive conformation of Raf-1 in which the Ras-binding Cysteine-rich domain (CRD) is obscured. The Raf-1 molecule contains an additional p21ras-binding domain (RBD), a second serine phosphorylation site at S621 (S2) and two tyrosine phosphorylation sites (at 340, Y1 and 341, Y2). Authored: Charalambous, M, 2005-01-07 11:17:43 |
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| definition source |
Reactome, http://www.reactome.org Pubmed9069260 |
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Transient dissociation of 14-3-3 upon Ras binding |
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HINO:0004539 |
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Transient dissociation of 14-3-3 upon Ras binding |
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| seeAlso |
Reactome Database ID Release 43109803 ReactomeREACT_359 |
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