loading...| Preferred Name |
p-RAF binds 14-3-3 beta/alpha |
|
| Synonyms |
|
|
| Definitions |
Edited: Schmidt, EE, 0000-00-00 00:00:00 Authored: Charalambous, M, 2005-01-07 11:17:43 Inactive Raf-1 is associated in the cytoplasm with 14-3-3. 14-3-3 binds to Raf-1 via the Ser259 phosphorylation site (S1). This interaction stabilises the inactive conformation of Raf-1 in which the Ras-binding Cysteine-rich domain (CRD) is obscured. The Raf-1 molecule contains an additional p21ras-binding domain (RBD), a second serine phosphorylation site at S621 (S2) and two tyrosine phosphorylation sites (at 340, Y1 and 341, Y2). |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0004538 |
|
| comment |
Edited: Schmidt, EE, 0000-00-00 00:00:00 Authored: Charalambous, M, 2005-01-07 11:17:43 Inactive Raf-1 is associated in the cytoplasm with 14-3-3. 14-3-3 binds to Raf-1 via the Ser259 phosphorylation site (S1). This interaction stabilises the inactive conformation of Raf-1 in which the Ras-binding Cysteine-rich domain (CRD) is obscured. The Raf-1 molecule contains an additional p21ras-binding domain (RBD), a second serine phosphorylation site at S621 (S2) and two tyrosine phosphorylation sites (at 340, Y1 and 341, Y2). |
|
| definition source |
Reactome, http://www.reactome.org Pubmed9069260 |
|
| has input | ||
| has output | ||
| label |
p-RAF binds 14-3-3 beta/alpha |
|
| prefixIRI |
HINO:0004538 |
|
| prefLabel |
p-RAF binds 14-3-3 beta/alpha |
|
| seeAlso |
ReactomeREACT_2158 Reactome Database ID Release 43109804 |
|
| subClassOf |