Human Interaction Network Ontology

Last uploaded: June 27, 2014
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Id http://purl.obolibrary.org/obo/HINO_0004511
http://purl.obolibrary.org/obo/HINO_0004511
Preferred Name

Pro-EGF is cleaved to form mature EGF
Definitions
Ligands of the epidermal growth factor receptor (EGFR) are shed from the plasma membrane by metalloproteases. Identification of the sheddases for EGFR ligands using mouse embryonic cells lacking candidate sheddases (a disintegrin and metalloprotease; ADAM) has revealed that ADAM10, -12 and -17 are the sheddases of the EGFR ligands in response to various shedding stimulants such as GPCR agonists, growth factors, cytokines, osmotic stress, wounding and phorbol ester. Among the EGFR ligands, heparin-binding EGF-like growth factor (HB-EGF), EGF and TGF-alpha are the best characterized. Reviewed: Muthuswamy, S, 2007-02-16 20:08:05 Authored: Castagnoli, L, 2006-10-10 13:09:34
Type http://www.w3.org/2002/07/owl#Class

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label
Pro-EGF is cleaved to form mature EGF
comment
Ligands of the epidermal growth factor receptor (EGFR) are shed from the plasma membrane by metalloproteases. Identification of the sheddases for EGFR ligands using mouse embryonic cells lacking candidate sheddases (a disintegrin and metalloprotease; ADAM) has revealed that ADAM10, -12 and -17 are the sheddases of the EGFR ligands in response to various shedding stimulants such as GPCR agonists, growth factors, cytokines, osmotic stress, wounding and phorbol ester. Among the EGFR ligands, heparin-binding EGF-like growth factor (HB-EGF), EGF and TGF-alpha are the best characterized.
Reviewed: Muthuswamy, S, 2007-02-16 20:08:05
Authored: Castagnoli, L, 2006-10-10 13:09:34
prefLabel
Pro-EGF is cleaved to form mature EGF
definition source
Reactome, http://www.reactome.org
prefixIRI
HINO:0004511
seeAlso
ReactomeREACT_9423
EC Number: 3.4.24
Reactome Database ID Release 43177946
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