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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
| Id | http://purl.obolibrary.org/obo/HINO_0014356
http://purl.obolibrary.org/obo/HINO_0014356
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|---|---|
| Preferred Name | Dissociation of the PAR:Gq complex |
| Definitions |
Authored: Akkerman, JW, 2009-09-04
The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (s) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).
Edited: Jupe, S, 2010-06-07
Reviewed: Kunapuli, SP, 2010-06-07
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | Dissociation of the PAR:Gq complex
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| label | Dissociation of the PAR:Gq complex
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| comment | Authored: Akkerman, JW, 2009-09-04
The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (s) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).
Edited: Jupe, S, 2010-06-07
Reviewed: Kunapuli, SP, 2010-06-07
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| seeAlso |
Reactome Database ID Release 43397835
ReactomeREACT_23818
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| has input | |
| type | |
| definition source |
Pubmed18577758
Reactome, http://www.reactome.org
Pubmed8736705
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| prefixIRI | HINO:0014356
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| subClassOf |
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