Human Health Exposure Analysis Resource

Last uploaded: July 19, 2024
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Id http://purl.obolibrary.org/obo/CL_0000037
http://purl.obolibrary.org/obo/CL_0000037
Preferred Name

hematopoietic stem cell
Definitions
A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative.
Synonyms
colony forming unit hematopoietic
HSC
blood forming stem cell
hemopoietic stem cell
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119.

Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative.
alternative label
colony forming unit hematopoietic
HSC
blood forming stem cell
hemopoietic stem cell
preferred label
hematopoietic stem cell
label
hematopoietic stem cell
comment
Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative.
prefLabel
hematopoietic stem cell
database_cross_reference
MESH:D006412
BTO:0000725
CALOHA:TS-0448
ZFA:0009014
VHOG:0001485
FMA:86475
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colony forming unit hematopoietic
HSC
note
A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119.
Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative.
prefixIRI
CL:0000037
functionally related to
present in taxon
capable of
capable of part of
subClassOf
develops_from
type
lacks_plasma_membrane_part
has exact synonym
blood forming stem cell
hemopoietic stem cell
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