Preferred Name

estradiol

Synonyms
Definitions

The most potent form of the naturally occurring steroid sex hormone in humans, produced by ovary, placenta, testis, and in small amount by adrenal cortex. Estradiol binds to a specific intracellular estrogen receptor located in female organs, breasts, hypothalamus and pituitary. The receptor-ligand complex promotes gene expression necessary for the maintenance of fertility and secondary sexual characteristics in females. In addition, estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. Estradiol, the principal intracellular human estrogen, is substantially more active at the cellular level than its metabolites, estrone and estriol. The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.

ID

http://purl.obolibrary.org/obo/CHEBI_23965

ATC Code

G03CA03

ChEBI ID

http://purl.obolibrary.org/obo/CHEBI_23965

definition

The most potent form of the naturally occurring steroid sex hormone in humans, produced by ovary, placenta, testis, and in small amount by adrenal cortex. Estradiol binds to a specific intracellular estrogen receptor located in female organs, breasts, hypothalamus and pituitary. The receptor-ligand complex promotes gene expression necessary for the maintenance of fertility and secondary sexual characteristics in females. In addition, estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. Estradiol, the principal intracellular human estrogen, is substantially more active at the cellular level than its metabolites, estrone and estriol.

The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.

has database cross reference

https://en.wikipedia.org/wiki/Estradiol

https://en.wikipedia.org/wiki/Estradiol_(medication)

https://en.wikipedia.org/wiki/Category:Estradiol

is referenced by

https://books.google.com/books/?id=ymkYAAAAIAAJ

label

estradiol

Library of Congress Classification

QP572.E8

Library of Congress Subject Headings

http://id.loc.gov/authorities/subjects/sh85045006

Medical Dictionary for Regulatory Activities ID

http://purl.bioontology.org/ontology/MEDDRA/10015499

MeSH Descriptor ID

http://purl.bioontology.org/ontology/MESH/D004958

NCI Thesaurus ID

http://purl.obolibrary.org/obo/NCIT_C2295

prefixIRI

CHEBI:23965

prefLabel

estradiol

SNOMED CT Identifier

http://purl.bioontology.org/ontology/SNOMEDCT/126172005

subClassOf

http://purl.obolibrary.org/obo/CHEBI_36838

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