Preferred Name |
estradiol |
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Synonyms |
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Definitions |
The most potent form of the naturally occurring steroid sex hormone in humans, produced by ovary, placenta, testis, and in small amount by adrenal cortex. Estradiol binds to a specific intracellular estrogen receptor located in female organs, breasts, hypothalamus and pituitary. The receptor-ligand complex promotes gene expression necessary for the maintenance of fertility and secondary sexual characteristics in females. In addition, estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. Estradiol, the principal intracellular human estrogen, is substantially more active at the cellular level than its metabolites, estrone and estriol. The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. |
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ID |
http://purl.obolibrary.org/obo/CHEBI_23965 |
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ATC Code |
G03CA03 |
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ChEBI ID | ||
definition |
The most potent form of the naturally occurring steroid sex hormone in humans, produced by ovary, placenta, testis, and in small amount by adrenal cortex. Estradiol binds to a specific intracellular estrogen receptor located in female organs, breasts, hypothalamus and pituitary. The receptor-ligand complex promotes gene expression necessary for the maintenance of fertility and secondary sexual characteristics in females. In addition, estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. Estradiol, the principal intracellular human estrogen, is substantially more active at the cellular level than its metabolites, estrone and estriol. The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. |
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has database cross reference |
https://en.wikipedia.org/wiki/Estradiol |
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is referenced by | ||
label |
estradiol |
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Library of Congress Classification |
QP572.E8 |
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Library of Congress Subject Headings | ||
Medical Dictionary for Regulatory Activities ID | ||
MeSH Descriptor ID | ||
NCI Thesaurus ID | ||
prefixIRI |
CHEBI:23965 |
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prefLabel |
estradiol |
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SNOMED CT Identifier | ||
subClassOf |