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Last uploaded: November 12, 2024
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Preferred Name

AKT kinase
Synonyms

PKB

serine-threonine kinase Akt

AKT
Definitions

A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites.
ID

http://purl.obolibrary.org/obo/PR_000029189
definition

A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites.
has_broad_synonym

PKB
has_exact_synonym

serine-threonine kinase Akt

AKT
label

AKT kinase
prefixIRI

PR:000029189
prefLabel

AKT kinase
subClassOf

http://purl.obolibrary.org/obo/PR_000000001

http://purl.obolibrary.org/obo/CHEBI_36080
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