loading...| Preferred Name | TGF-beta-like cystine-knot cytokine | |
| Synonyms |
TGF-beta superfamily |
|
| Definitions |
A protein that has a core domain composition consisting of a signal peptide, a variable propeptide region and a Transforming growth factor beta like domain (Pfam:PF00019), which is a cystine-knot domain containing four conserved beta strands, S1-S4, which form two antiparallel beta sheets (SI-S2 and S3-S4) interconnected by three disulfide bridges in a knot-like topology. Cystines [II-V] and [III-VI] form a ring through which the remaining disulfide bond (Cys[I-IV]) penetrates. Insertion of different variable regions into this common motif has given rise to various subclasses of the growth factor cystine-knot domain. |
|
| ID |
http://purl.obolibrary.org/obo/PR_000000008 |
|
| definition |
A protein that has a core domain composition consisting of a signal peptide, a variable propeptide region and a Transforming growth factor beta like domain (Pfam:PF00019), which is a cystine-knot domain containing four conserved beta strands, S1-S4, which form two antiparallel beta sheets (SI-S2 and S3-S4) interconnected by three disulfide bridges in a knot-like topology. Cystines [II-V] and [III-VI] form a ring through which the remaining disulfide bond (Cys[I-IV]) penetrates. Insertion of different variable regions into this common motif has given rise to various subclasses of the growth factor cystine-knot domain. |
|
| has_related_synonym |
TGF-beta superfamily |
|
| label |
TGF-beta-like cystine-knot cytokine |
|
| prefixIRI |
PR:000000008 |
|
| prefLabel |
TGF-beta-like cystine-knot cytokine |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/PR_000000008 | PR | SAME_URI | |
| http://purl.obolibrary.org/obo/PR_000000008 | CIDO | SAME_URI | |
| http://purl.obolibrary.org/obo/PR_000000008 | UPHENO | SAME_URI | |
| http://purl.obolibrary.org/obo/PR_000000008 | NIFSTD | SAME_URI | |
| http://purl.obolibrary.org/obo/PR_000000008 | OBA | SAME_URI | |
| http://purl.obolibrary.org/obo/PR_000000008 | PR | LOOM | |
| http://purl.obolibrary.org/obo/PR_000000008 | CIDO | LOOM | |
| http://purl.obolibrary.org/obo/PR_000000008 | UPHENO | LOOM | |
| http://purl.obolibrary.org/obo/PR_000000008 | NIFSTD | LOOM | |
| http://purl.obolibrary.org/obo/PR_000000008 | OBA | LOOM |