FuTRES Ontology of Vertebrate Traits

Last uploaded: May 31, 2023
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Id http://purl.obolibrary.org/obo/UBERON_0000949
http://purl.obolibrary.org/obo/UBERON_0000949
Preferred Name

endocrine system
Definitions
Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity.
Synonyms
endocrine system
systema endocrinum
endocrine glandular system
Type http://www.w3.org/2002/07/owl#Class

All Properties

label
endocrine system
prefLabel
endocrine system
database_cross_reference
FBbt:00005068
CALOHA:TS-1301
UMLS:C0014136
ZFA:0001158
MESH:D004703
EMAPA:35306
SCTID:278876000
NCIT:C12705
AAO:0010279
VHOG:0000098
TAO:0001158
XAO:0000158
Wikipedia:Endocrine_system
EHDAA2:0002224
EFO:0002969
EV:0100128
FMA:9668
GAID:439
MA:0000012
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notation
UBERON:0000949
inSubset
id
UBERON:0000949
has part
hasOBONamespace
uberon
UBPROP_0000007
endocrine
UBPROP_0000001
Anatomical system containing glands which regulates bodily functions though the secretion of hormones.[AAO]
UBPROP_0000003
Multicellular organisms have complex endocrine systems, allowing responses to environmental stimuli, regulation of development, reproduction, and homeostasis. Nuclear receptors (NRs), a metazoan-specific family of ligand-activated transcription factors, play central roles in endocrine responses, as intermediates between signaling molecules and target genes. The NR family includes ligand-bound and orphan receptors, that is, receptors with no known ligand or for which there is no ligand Pocket. Understanding NR evolution has been further improved by comparison of several completed genomes, particularly those of deuterostomes and ecdysozoans. In contrast, evolution of NR ligands is still much debated. One hypothesis proposes that several independent gains and losses of ligand-binding ability in NRs occurred in protostomes and deuterostomes. A second hypothesis, pertaining to the NR3 subfamily (vertebrate steroid hormone receptors and estrogen related receptor), proposes that before the divergence of protostomes and deuterostomes, there was an ancestral steroid receptor (AncSR) that was ligand-activated and that orphan receptors secondarily lost the ability to bind a ligand. (...) Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages (...).[well established][VHOG]
textual definition
Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity.
functionally related to
capable of
capable of part of
subClassOf
overlaps
composed primarily of
type
has_exact_synonym
endocrine system
systema endocrinum
endocrine glandular system
existence ends during or before
existence ends during
in taxon
only in taxon
disjointWith
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