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FuTRES Ontology of Vertebrate Traits
Last uploaded:
May 31, 2023
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| Id | http://purl.obolibrary.org/obo/CL_0000134
http://purl.obolibrary.org/obo/CL_0000134
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|---|---|
| Preferred Name | mesenchymal stem cell |
| Definitions |
A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs.
Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
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| Synonyms |
colony-forming unit-fibroblast
marrow stromal cells
bone marrow stromal cells
BMSC
stem cells, mesenchymal
mesenchymal progenitor cells
mesenchymal stromal cell
mesenchymal stromal cells
mesenchymal stem cell
mesenchymal precursor cell
CFU-F
MSC
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
mesenchymal stem cell
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|---|---|
| comment |
Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
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| prefLabel |
mesenchymal stem cell
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| database_cross_reference |
BTO:0003298
BTO:0002625
FMA:70546
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| hasNarrowSynonym |
colony-forming unit-fibroblast
marrow stromal cells
bone marrow stromal cells
BMSC
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| has_related_synonym |
stem cells, mesenchymal
mesenchymal progenitor cells
mesenchymal stromal cell
mesenchymal stromal cells
mesenchymal stem cell
mesenchymal precursor cell
CFU-F
MSC
See more
See less
|
| prefixIRI |
CL:0000134
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| seeAlso | |
| textual definition |
A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs.
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| subClassOf | |
| type |
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