Epilepsy_Disease

http://www.semanticweb.org/rjyy/ontologies/2015/5/ESSO#Epilepsy_Disease

Epilepsy_Disease

Luders 1998 Epilepsy classification The semiological seizure classification is a classification of the semiology of the seizures only. The epileptic syndrome, however, is defined by considering all clinical information (semiological seizure type, interictal EEG, ictal EEG, functional and anatomic neuroimaging, seizure evolution over time, neurological examination, and so on). In our institutions, we first define the epiteptic syndrome, then list the semiological characteristics of the patient’s seizures, state the presumed cause of the epileptic syndrome, and record important additional medical conditions which the patient has. This approach summarizes the essential features of the epilepsy and has been described in detail elsewhere (6). Some illustrative examples follow. 1. Left Mesial Temporal Lobe Epilepsy Seizures: Abdominal aura --> automotor seizure Cause: Left mesial temporal sclerosis Related medical conditions: Febrile convulsions, Memory deficit, Cerebellar atrophy 2. Absence Epilepsy Seizures: Typical dialeptic seizure --> generalized tonic-clonic seizure Cause: Genetic Related medical conditions:None 3. Lennox-Gastaut syndrome Seizures: Generalized tonic seizure, Dialeptic seizure, Astatic seizure Cause: Tuberous sclerosis Related medical conditions: Mental retardation, Depression 4. Right Frontal Epilepsy Seizures: Asymmetric bilateral tonic seizure --> Left arm clonic seizure --> Generalized tonic clonic seizure Cause: Right mesial frontal cortical dysplasia Related medical conditions: Schizophrenia, Mild mental retardation Engel 2006 Epilepsy disease: A pathological condition with a single specific, well-defined etiology. Thus, progressive myoclonus epilepsy is a syndrome, but Unverricht–Lundborg is a disease (new concept). Scheuermann 2009 Epilepsy as a disease that disposes to the occurrence of seizures (pathological processes) due to an underlying abnormality in the neuronal circuitry of the brain (physical basis) Fischer 2014 Definition is usually practically applied as having two unprovoked seizures >24 h apart. The task force proposed that epilepsy be considered to be a diseaseof the brain defined by any of the following conditions: (1) At least two unprovoked (or reflex) seizures occurring >24 h apart; (2) one unprovoked (or reflex) seizure and a probability of further seizures similar to the general recurrence risk (at least 60%) after two unprovoked seizures, occurring over the next 10 years; (3) diagnosis of an epilepsy syndrome Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures, and by theneurobiologic, cognitive, psychological, and social consequences of this condition. The definition of epilepsy requires the occurrence of at least one epileptic seizure. Term disease may (butnot always) convey a more lasting derangement of normal function The ILAE and the International Bureau for Epilepsy (IBE) have recently agreed that epilepsy is best considered to be a disease. Epilepsy exists in a patient who has had a seizure and whose brain, for whatever reason, demonstrates a pathologic and enduring tendency to have recurrent seizures. This tendency can be imagined as a pathologic lowering of the seizure threshold, when compared to persons without the condition. It makes little sense to say that someone has an epilepsy syndrome but not epilepsy. If evidence exists for an epilepsy syndrome, then epilepsy may be presumed to be present, even if the risk of subsequent seizures is low.

http://www.semanticweb.org/rjyy/ontologies/2015/5/ESSO#Luders_1998_7.0_Epilepsy_Classification

http://www.semanticweb.org/rjyy/ontologies/2015/5/ESSO#Blume_2001_I_4.1_Epileptic_Disorder

http://www.semanticweb.org/rjyy/ontologies/2015/5/ESSO#Blume_2001_I_4.0_Epilepsy

http://www.semanticweb.org/rjyy/ontologies/2015/5/ESSO#Engel_2001_2.03_Epilepsy_Disease

http://www.semanticweb.org/rjyy/ontologies/2015/5/ESSO#Blume_2001_I_4.2_Epilepsies

http://www.semanticweb.org/rjyy/ontologies/2015/5/ESSO#Disease