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July 12, 2023
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77548
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77548
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|---|---|
| Preferred Name | Gadoxetate Disodium |
| Definitions |
A paramagnetic contrast agent consisting of the disodium salt of the gadolinium ion chelated with the lipophilic moiety ethoxybenzyl (EOB) bound to diethylenetriamine pentaacetic acid (DTPA). When placed in a magnetic field, gadolinium produces a large magnetic moment and so a large local magnetic field, which can enhance the relaxation rate of nearby protons; as a result, the signal intensity of tissue images observed with magnetic resonance imaging (MRI) may be enhanced. Because this agent is preferentially taken up by normal functioning hepatocytes, normal hepatic tissue is enhanced with MRI while tumor tissue is unenhanced. In addition, because this agent is excreted in the bile, it may be used to visualize the biliary system using MRI.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label | Gadoxetate Disodium
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|---|---|
| prefLabel | Gadoxetate Disodium
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| Legacy Concept Name | Gadoxetate_Disodium
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| NCI_Drug_Dictionary_ID | 617182
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| PDQ_Closed_Trial_Search_ID | 617182
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| Preferred_Name | Gadoxetate Disodium
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| Display_Name | Gadoxetate Disodium
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| Semantic_Type |
Organic Chemical
Indicator, Reagent, or Diagnostic Aid
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| prefixIRI | Thesaurus:C77548
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| DEFINITION | A paramagnetic contrast agent consisting of the disodium salt of the gadolinium ion chelated with the lipophilic moiety ethoxybenzyl (EOB) bound to diethylenetriamine pentaacetic acid (DTPA). When placed in a magnetic field, gadolinium produces a large magnetic moment and so a large local magnetic field, which can enhance the relaxation rate of nearby protons; as a result, the signal intensity of tissue images observed with magnetic resonance imaging (MRI) may be enhanced. Because this agent is preferentially taken up by normal functioning hepatocytes, normal hepatic tissue is enhanced with MRI while tumor tissue is unenhanced. In addition, because this agent is excreted in the bile, it may be used to visualize the biliary system using MRI.
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| UMLS_CUI | C1714000
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| 文本定义 | A paramagnetic contrast agent consisting of the disodium salt of the gadolinium ion chelated with the lipophilic moiety ethoxybenzyl (EOB) bound to diethylenetriamine pentaacetic acid (DTPA). When placed in a magnetic field, gadolinium produces a large magnetic moment and so a large local magnetic field, which can enhance the relaxation rate of nearby protons; as a result, the signal intensity of tissue images observed with magnetic resonance imaging (MRI) may be enhanced. Because this agent is preferentially taken up by normal functioning hepatocytes, normal hepatic tissue is enhanced with MRI while tumor tissue is unenhanced. In addition, because this agent is excreted in the bile, it may be used to visualize the biliary system using MRI.
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| code | C77548
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| Chemical_Formula | C23H28N3O11.Gd.2Na
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| subClassOf | |
| type | |
| CAS_Registry | 135326-22-6
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| FULL_SYN | Disodium (N-((2S)-2-(bis(carboxymethyl)amino)-3-(p-ethoxyphenyl)propyl)-N-(2-(bis(carboxymethyl)amino)ethyl)glycinato(5-))gadolinate(2-)
Gd-EOB-DTPA
Gd-(S)-EOB-DTPA
Gadolinium Ethoxybenzyl Diethylenetriamine Pentaacetic Acid
Gadoxetate Disodium
GADOXETATE DISODIUM
Gadoxetic Acid Disodium
Gadolinium Ethoxybenzyl Diethylenetriaminepentaacetic Acid
Gadolinium EOB DTPA
Eovist
Primovist
ZK 139834
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| FDA_UNII_Code | HOY74VZE0M
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| PDQ_Open_Trial_Search_ID | 617182
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| Contributing_Source |
CTRP
FDA
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| Concept_In_Subset | |
| Has_Free_Acid_Or_Base_Form |
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