Link to this page
eNanoMapper
| Preferred Name | Ditiocarb | |
| Synonyms |
|
|
| Definitions |
A sulfhydryl-containing carbamate that is the primary in vivo metabolite of disulfiram. Diethyldithiocarbamate chelates zinc, thereby inhibiting metalloproteinases, thereby preventing the degradation of the extracellular matrix and inhibiting an initial step in cancer metastasis and angiogenesis. A known inhibitor of superoxide dismutase, this agent can either potentiate or protect against cell oxidative damage caused by ionizing radiation, depending on the time of administration. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C432 |
|
| CAS_Registry |
147-84-2
|
|
| Chemical_Formula |
C5H11NS2
|
|
| code |
C432
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA
|
|
| DEFINITION |
A sulfhydryl-containing carbamate that is the primary in vivo metabolite of disulfiram. Diethyldithiocarbamate chelates zinc, thereby inhibiting metalloproteinases, thereby preventing the degradation of the extracellular matrix and inhibiting an initial step in cancer metastasis and angiogenesis. A known inhibitor of superoxide dismutase, this agent can either potentiate or protect against cell oxidative damage caused by ionizing radiation, depending on the time of administration. (NCI04)
|
|
| FDA_UNII_Code |
99Z2744345
|
|
| FULL_SYN |
Diethyldithiocarbaminic Acid Diethyldithiocarbamate Diethylcarbamodithioic Acid Diethyldithiocarbamic Acid Diethyldithione Diethyldione DDTC DIECA DITIOCARB DTC Ditiocarb
|
|
| Is_Value_For_GDC_Property | ||
| label |
Ditiocarb
|
|
| Legacy Concept Name |
Diethyldithiocarbamate
|
|
| Maps_To |
Ditiocarb
|
|
| NCI_Drug_Dictionary_ID |
40247
|
|
| PDQ_Closed_Trial_Search_ID |
40247
|
|
| PDQ_Open_Trial_Search_ID |
40247
|
|
| Preferred_Name |
Ditiocarb
|
|
| prefixIRI |
Thesaurus:C432
|
|
| prefLabel |
Ditiocarb
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
|
|
| UMLS_CUI |
C0012194
|
|
| 文本定义 |
A sulfhydryl-containing carbamate that is the primary in vivo metabolite of disulfiram. Diethyldithiocarbamate chelates zinc, thereby inhibiting metalloproteinases, thereby preventing the degradation of the extracellular matrix and inhibiting an initial step in cancer metastasis and angiogenesis. A known inhibitor of superoxide dismutase, this agent can either potentiate or protect against cell oxidative damage caused by ionizing radiation, depending on the time of administration. (NCI04)
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |