Experimental Factor Ontology

Last uploaded: October 15, 2019
Preferred Name

pancreas

Synonyms

Entire pancreas

Definitions

taxon notes: As a secretory organ serving exocrine and endocrine functions, the pancreas is specific to the vertebrates[PMID:16417468] Hagfishes and lampreys are unique in the complete separation of their endocrine pancreas (islet or- gan) and their exocrine pancreas (50). The endocrine and exocrine pancreas are coassociated in crown gnathostomes (50). In Branchiostoma and Ciona, there is no diverticulum as there is in hagfishes, lampreys, and gnathostomes, only dispersed insulin-secreting cells in the walls of the gastrointestinal tract (51, 52) [PMID:20959416]. The zebrafish does not have a discrete pancreas. Exocrine pancreatic tissue can be found scattered along the intestinal tract (Figures 16 and 17 ). The acinar structure of the exocrine pancreas is very similar to that of mammals and comprises cells with a very dark, basophilic cytoplasm An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes[GO]. The mature pancreas of higher vertebrates and mammals comprises two major functional units: the exocrine pancreas, which is responsible for the production of digestive enzymes to be secreted into the gut lumen, and the endocrine pancreas, which has its role in the synthesis of several hormones with key regulatory functions in food uptake and metabolism. The exocrine portion constitutes the majority of the mass of the pancreas, and contains only two different cell types, the secretory acinar cells and the ductular cells. The endocrine portion, which comprises only 1–2% of the total mass, contains five different cell types, which are organized into mixed functional assemblies referred to as the islets of Langerhans[PMID]. An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes[GO].

ID

http://purl.obolibrary.org/obo/UBERON_0001264

comment

taxon notes: As a secretory organ serving exocrine and endocrine functions, the pancreas is specific to the vertebrates[PMID:16417468] Hagfishes and lampreys are unique in the complete separation of their endocrine pancreas (islet or- gan) and their exocrine pancreas (50). The endocrine and exocrine pancreas are coassociated in crown gnathostomes (50). In Branchiostoma and Ciona, there is no diverticulum as there is in hagfishes, lampreys, and gnathostomes, only dispersed insulin-secreting cells in the walls of the gastrointestinal tract (51, 52) [PMID:20959416]. The zebrafish does not have a discrete pancreas. Exocrine pancreatic tissue can be found scattered along the intestinal tract (Figures 16 and 17 ). The acinar structure of the exocrine pancreas is very similar to that of mammals and comprises cells with a very dark, basophilic cytoplasm

database_cross_reference

BTO:0000988

TAO:0000140

http://upload.wikimedia.org/wikipedia/commons/thumb/3/3f/Illu_pancrease.svg/200px-Illu_pancrease.svg.png

EV:0100092

ZFA:0000140

UMLS:C0030274

http://upload.wikimedia.org/wikipedia/commons/3/3f/Illu_pancrease.svg

XAO:0000136

EMAPA:17503

MIAA:0000075

galen:Pancreas

AAO:0010112

MESH:D010179

EHDAA:6893

OpenCyc:Mx4rvVimZZwpEbGdrcN5Y29ycA

CALOHA:TS-0736

MAT:0000075

Wikipedia:Pancreas

MESH:A03.734

FMA:7198

MSH:D010179

EFO:0000855

EMAPA:18816

MA:0000120

VHOG:0000050

GAID:334

SNOMEDCT:181277001

NCIt:C12393

NCIT:C12393

EHDAA2:0001367

http://linkedlifedata.com/resource/umls/id/C0030274

http://en.wikipedia.org/wiki/Pancreas

http://www.snomedbrowser.com/Codes/Details/181277001

definition

An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes[GO]. The mature pancreas of higher vertebrates and mammals comprises two major functional units: the exocrine pancreas, which is responsible for the production of digestive enzymes to be secreted into the gut lumen, and the endocrine pancreas, which has its role in the synthesis of several hormones with key regulatory functions in food uptake and metabolism. The exocrine portion constitutes the majority of the mass of the pancreas, and contains only two different cell types, the secretory acinar cells and the ductular cells. The endocrine portion, which comprises only 1–2% of the total mass, contains five different cell types, which are organized into mixed functional assemblies referred to as the islets of Langerhans[PMID].

An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes[GO].

depicted_by

https://upload.wikimedia.org/wikipedia/commons/7/7e/Blausen_0699_PancreasAnatomy2.png

external_definition

Organ which secretes a fluid containing enzymes that aid in the digestion of food.[AAO]

has_exact_synonym

Entire pancreas

has_obo_namespace

uberon

has_relational_adjective

pancreatic

homologous_in

http://purl.obolibrary.org/obo/NCBITaxon_7742

homology_notes

In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]

id

UBERON:0001264

in_subset

http://purl.obolibrary.org/obo/uberon#major_organ

http://purl.obolibrary.org/obo/uberon#efo_slim

http://purl.obolibrary.org/obo/uberon/core#major_organ

http://purl.obolibrary.org/obo/uberon#vertebrate_core

http://purl.obolibrary.org/obo/uberon/core#uberon_slim

http://purl.obolibrary.org/obo/uberon/core#organ_slim

http://purl.obolibrary.org/obo/uberon/core#pheno_slim

http://purl.obolibrary.org/obo/uberon/core#efo_slim

http://purl.obolibrary.org/obo/uberon#uberon_slim

http://purl.obolibrary.org/obo/uberon/core#vertebrate_core

http://purl.obolibrary.org/obo/uberon#organ_slim

label

pancreas

notation

UBERON:0001264

part_of

http://purl.obolibrary.org/obo/UBERON_0002100

http://purl.obolibrary.org/obo/UBERON_0000949

prefLabel

pancreas

taxon_notes

The zebrafish does not have a discrete pancreas. Exocrine pancreatic tissue can be found scattered along the intestinal tract. The acinar structure of the exocrine pancreas is very similar to that of mammals and comprises cells with a very dark, basophilic cytoplasm

As a secretory organ serving exocrine and endocrine functions, the pancreas is specific to the vertebrates[PMID:16417468] Hagfishes and lampreys are unique in the complete separation of their endocrine pancreas (islet or- gan) and their exocrine pancreas (50). The endocrine and exocrine pancreas are coassociated in crown gnathostomes (50). In Branchiostoma and Ciona, there is no diverticulum as there is in hagfishes, lampreys, and gnathostomes, only dispersed insulin-secreting cells in the walls of the gastrointestinal tract (51, 52)

treeView

http://purl.obolibrary.org/obo/UBERON_0002100

http://purl.obolibrary.org/obo/UBERON_0000949

UBPROP_0000009

The mature pancreas of higher vertebrates and mammals comprises two major functional units: the exocrine pancreas, which is responsible for the production of digestive enzymes to be secreted into the gut lumen, and the endocrine pancreas, which has its role in the synthesis of several hormones with key regulatory functions in food uptake and metabolism. The exocrine portion constitutes the majority of the mass of the pancreas, and contains only two different cell types, the secretory acinar cells and the ductular cells. The endocrine portion, which comprises only 1-2% of the total mass, contains five different cell types, which are organized into mixed functional assemblies referred to as the islets of Langerhans

disjointWith

http://purl.obolibrary.org/obo/UBERON_0010264

subClassOf

http://purl.obolibrary.org/obo/UBERON_0002075

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Delete Mapping To Ontology Source
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