loading...| Preferred Name | Decreased response to growth hormone stimulation test | |
| Synonyms |
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| Definitions |
Insufficient responses to growth hormone (GH) provocation tests. GH deficiency is defined as a serum peak GH concentration less than 10 ng/mL on provocation with a combination of at least two separate stimulation tests. GH stimulation tests are performed with various stimuli, such as insulin, L-dopa, arginine, and growth hormone releasing hormone (GHRH). The test using insulin as a stimulus is classically recommended, but this test has potential risks such as hypoglycemia. The effects of growth hormone are mediated almost exclusively by insulin-like growth factor 1(IGF-1), which is produced primarily in the liver. Growth hormone deficiency refers to inadequate levels of GH (and therefore IGF-1), resulting in growth retardation in children and metabolic disturbances in adults. |
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| ID |
http://purl.obolibrary.org/obo/HP_0000824 |
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| comment |
GH stimulation tests are performed with various stimuli, such as insulin, L-dopa, arginine, and growth hormone releasing hormone (GHRH). The test using insulin as a stimulus is classically recommended, but this test has potential risks such as hypoglycemia. The effects of growth hormone are mediated almost exclusively by insulin-like growth factor 1(IGF-1), which is produced primarily in the liver. Growth hormone deficiency refers to inadequate levels of GH (and therefore IGF-1), resulting in growth retardation in children and metabolic disturbances in adults. |
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| database_cross_reference |
SNOMEDCT_US:2109003 UMLS:C3714796 |
|
| definition |
Insufficient responses to growth hormone (GH) provocation tests. GH deficiency is defined as a serum peak GH concentration less than 10 ng/mL on provocation with a combination of at least two separate stimulation tests. |
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| has_alternative_id |
HP:0000861 HP:0008195 HP:0008206 |
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| id |
HP:0000824 |
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| label |
Decreased response to growth hormone stimulation test |
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| notation |
HP:0000824 |
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| preferred label |
Decreased response to growth hormone stimulation test |
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| prefLabel |
Decreased response to growth hormone stimulation test |
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| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/HP_0000824 | CCONT | SAME_URI | |
| http://purl.obolibrary.org/obo/HP_0000824 | SCDO | SAME_URI | |
| http://purl.obolibrary.org/obo/HP_0000824 | HP | SAME_URI | |
| http://purl.obolibrary.org/obo/HP_0000824 | UPHENO | SAME_URI | |
| http://purl.obolibrary.org/obo/HP_0000824 | OBA | SAME_URI | |
| http://purl.obolibrary.org/obo/HP_0000824 | CCONT | LOOM | |
| http://purl.obolibrary.org/obo/HP_0000824 | HP | LOOM | |
| http://purl.obolibrary.org/obo/HP_0000824 | UPHENO | LOOM | |
| http://purl.obolibrary.org/obo/HP_0000824 | OBA | LOOM |