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Experimental Factor Ontology
| Preferred Name | canonical NF-kappaB signal transduction | |
| Synonyms |
p50-dependent NF-kappaB signaling NF-kappaB cascade I-kappaB kinase/NF-kappaB signal transduction I-kappaB kinase/NF-kappaB signaling I-kappaB kinase/NF-kappaB cascade canonical NF-kappaB signaling cascade |
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| Definitions |
An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs). |
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| ID |
http://purl.obolibrary.org/obo/GO_0007249 |
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| definition |
An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs).
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| has_broad_synonym |
NF-kappaB cascade
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| has_exact_synonym |
I-kappaB kinase/NF-kappaB signal transduction I-kappaB kinase/NF-kappaB signaling I-kappaB kinase/NF-kappaB cascade canonical NF-kappaB signaling cascade
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| has_obo_namespace |
biological_process
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| has_related_synonym |
p50-dependent NF-kappaB signaling
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| IAO_0000233 | ||
| id |
GO:0007249
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| label |
canonical NF-kappaB signal transduction
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| notation |
GO:0007249
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| preferred label |
canonical NF-kappaB signal transduction
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| prefLabel |
canonical NF-kappaB signal transduction
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| subClassOf |
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