Tclin drug target

Tclin drug target

Drug targets are entities with molecular mass present in living systems that, upon interaction with therapeutic agents or their byproducts, result in modified biologic responses that lead to therapeutic outcomes. Here “living systems” encompass humans or animals (e.g., for veterinary medicines) and foreign organisms such as viruses, bacteria or parasites that may be infest humans or animals. The interaction between a drug and its target results in observable clinical outcomes. For drug targets, “mode of action” (MoA), referred to as “mechanism of action” when the molecular interactions are well understood, describes the way in which drugs exert their intended therapeutic action, resulting in the intended therapeutic outcome, i.e., the indication(s) stated on the approved drug label, or otherwise the desired outcome (for off-label usage). Some drug-target interactions may lead to unintended clinical outcomes, i.e., side effects or adverse drug reactions. While side effects can be mediated by MoA targets, they are often the result of the interaction between the drug or its metabolites and other proteins. (resource: IDG)

dto:DTO_00000005

IDG; http://www.nature.com/nrd/posters/druggablegenome/nrd_druggablegenome.pdf