Preferred Name |
Prednisone |
|
Synonyms |
17,21-dihydroxypregna-1,4-diene-3,11,20-trione 1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione 1,2-Dehydrocortisone Dehydrocortisone prednisonum 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione prednison prednisona prednisone |
|
Definitions |
A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid. |
|
ID |
http://purl.obolibrary.org/obo/CHEBI_8382 |
|
charge |
0 |
|
database_cross_reference |
Drug_Central:2253 PMID:23395281 CAS:53-03-2 PMID:23093541 DrugBank:DB00635 Patent:US2837464 Beilstein:2065301 Wikipedia:Prednisone Patent:US2579479 Patent:US2897216 PMID:10438974 PMID:18971570 Reaxys:2065301 PMID:15859934 Patent:US3134718 KEGG:C07370 |
|
definition |
A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid. |
|
formula |
C21H26O5 |
|
has role |
http://purl.obolibrary.org/obo/CHEBI_35705 http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_37962 |
|
has_exact_synonym |
17,21-dihydroxypregna-1,4-diene-3,11,20-trione |
|
has_obo_namespace |
chebi_ontology |
|
has_related_synonym |
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione 1,2-Dehydrocortisone Dehydrocortisone prednisonum 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione prednison prednisona prednisone |
|
has_RxCUI |
8640 |
|
id |
CHEBI:8382 |
|
in_subset | ||
inchi |
InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 |
|
inchikey |
XOFYZVNMUHMLCC-ZPOLXVRWSA-N |
|
is_bearer_of | ||
label |
Prednisone prednisone |
|
mass |
358.42810 |
|
monoisotopicmass |
358.17802 |
|
notation |
CHEBI:8382 |
|
prefLabel |
Prednisone |
|
smiles |
[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])C(=O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO |
|
subClassOf |
http://purl.obolibrary.org/obo/CHEBI_139590 http://purl.obolibrary.org/obo/CHEBI_139592 http://purl.obolibrary.org/obo/CHEBI_36885 http://purl.obolibrary.org/obo/CHEBI_24261 http://purl.obolibrary.org/obo/CHEBI_77166 http://purl.obolibrary.org/obo/CHEBI_35344 http://purl.obolibrary.org/obo/CHEBI_47787 |