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The Drug Ontology
Last uploaded:
December 20, 2024
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| Id | http://purl.obolibrary.org/obo/CHEBI_7575
http://purl.obolibrary.org/obo/CHEBI_7575
|
|---|---|
| Preferred Name | nimodipine |
| Definitions |
A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
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| Synonyms |
isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
nimodipinum
2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester
BAY e 9736
Nimotop
Periplum
nimodipine
nimodipino
2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Nimodipine
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|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm. |
|---|---|
| label |
nimodipine
|
| prefLabel |
nimodipine
|
| database_cross_reference |
Drug_Central:1937
PMID:21869451
KEGG:C07267
PMID:22262041
CAS:66085-59-4
PMID:8519001
PMID:22300914
Reaxys:459792
PMID:12137606
Patent:DE2117571
PMID:17110283
LINCS:LSM-1659
Wikipedia:Nimodipine
PMID:16180362
Patent:US3799934
DrugBank:DB00393
KEGG:D00438
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|
| notation |
CHEBI:7575
|
| in_subset | |
| inchi |
InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
|
| has_related_synonym |
isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
nimodipinum
2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester
BAY e 9736
Nimotop
Periplum
nimodipine
nimodipino
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|
| id |
CHEBI:7575
|
| charge |
0
|
| has_obo_namespace |
chebi_ontology
|
| formula |
C21H26N2O7
|
| subClassOf | |
| inchikey |
UIAGMCDKSXEBJQ-UHFFFAOYSA-N
|
| mass |
418.44030
|
| monoisotopicmass |
418.17400
|
| type | |
| smiles |
COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC(C)C
|
| has_RxCUI |
7426
|
| has role | |
| has_exact_synonym |
2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Nimodipine
|
| has characteristic | |
| alternative label |
isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
nimodipinum
2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester
BAY e 9736
Nimotop
Periplum
nimodipine
nimodipino
2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Nimodipine
See more
See less
|
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