loading...| Preferred Name | metolazone | |
| Synonyms |
metolazonum 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide Zaroxolyn metolazona metolazone 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide |
|
| Definitions |
A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_64354 |
|
| alternative label |
metolazonum 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide Zaroxolyn metolazona metolazone 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide |
|
| charge |
0 |
|
| database_cross_reference |
PMID:12671341 PMID:8870895 Wikipedia:Metolazone PMID:15095363 PMID:8205244 PMID:16717105 PMID:1593359 PMID:16538931 PMID:21387350 PMID:1886511 PMID:2071258 PMID:1928234 PMID:1946137 CAS:17560-51-9 Patent:US3360518 PMID:16189620 DrugBank:DB00524 Patent:US2008139593 PMID:9089428 LINCS:LSM-1680 Drug_Central:1783 PMID:21886902 PMID:16908225 PMID:8199745 KEGG:D00431 Reaxys:965506 |
|
| definition |
A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics. |
|
| formula |
C16H16ClN3O3S |
|
| has role |
http://purl.obolibrary.org/obo/CHEBI_35498 |
|
| has_alternative_id |
CHEBI:6903 |
|
| has_exact_synonym |
7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
metolazonum 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide Zaroxolyn metolazona metolazone |
|
| has_RxCUI |
6916 |
|
| id |
CHEBI:64354 |
|
| in_subset | ||
| inchi |
InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23) |
|
| inchikey |
AQCHWTWZEMGIFD-UHFFFAOYSA-N |
|
| is_bearer_of | ||
| label |
metolazone |
|
| mass |
365.83500 |
|
| monoisotopicmass |
365.06009 |
|
| notation |
CHEBI:64354 |
|
| prefLabel |
metolazone |
|
| smiles |
CC1Nc2cc(Cl)c(cc2C(=O)N1c1ccccc1C)S(N)(=O)=O |
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_35358 |