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The Drug Ontology
Last uploaded:
December 20, 2024
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| Id | http://purl.obolibrary.org/obo/CHEBI_18258
http://purl.obolibrary.org/obo/CHEBI_18258
|
|---|---|
| Preferred Name | 3,3',5-triiodo-L-thyronine |
| Definitions |
An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
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| Synonyms |
4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine
liothyronine
O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine
L-3,3',5-triiodothyronine
liothyroninum
L-3,5,3'-Triiodothyronine
Triiodothyronine
3,5,3'-Triiodothyronine
L-triiodothyronine
3,5,3'TRIIODOTHYRONINE
Liothyronine
3,5,3'-Triiodo-L-thyronine
liotironina
L-T3
T3
Tertroxin
Tresitope
3,3',5-triiodo-L-thyronine
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|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism. |
|---|---|
| label |
3,3',5-triiodo-L-thyronine
|
| prefLabel |
3,3',5-triiodo-L-thyronine
|
| database_cross_reference |
DrugBank:DB00279
KEGG:D08128
PMID:15206581
LINCS:LSM-3991
CAS:6893-02-3
Wikipedia:Triiodothyronine
KEGG:C02465
PMID:19339791
Drug_Central:1585
PMID:11738632
Reaxys:2710227
HMDB:HMDB0000265
PDBeChem:T3
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|
| notation |
CHEBI:18258
|
| in_subset | |
| inchi |
InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
|
| has_related_synonym |
4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine
liothyronine
O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine
L-3,3',5-triiodothyronine
liothyroninum
L-3,5,3'-Triiodothyronine
Triiodothyronine
3,5,3'-Triiodothyronine
L-triiodothyronine
3,5,3'TRIIODOTHYRONINE
Liothyronine
3,5,3'-Triiodo-L-thyronine
liotironina
L-T3
T3
Tertroxin
Tresitope
See more
See less
|
| id |
CHEBI:18258
|
| charge |
0
|
| has_obo_namespace |
chebi_ontology
|
| formula |
C15H12I3NO4
|
| subClassOf | |
| is tautomer of | |
| inchikey |
AUYYCJSJGJYCDS-LBPRGKRZSA-N
|
| mass |
650.97350
|
| monoisotopicmass |
650.79004
|
| has_alternative_id |
CHEBI:13059
CHEBI:45840
CHEBI:11701
CHEBI:11702
CHEBI:19894
CHEBI:9722
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|
| type | |
| smiles |
N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
|
| has_RxCUI |
10814
|
| has role | |
| has_exact_synonym |
3,3',5-triiodo-L-thyronine
|
| has characteristic | |
| alternative label |
4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine
liothyronine
O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine
L-3,3',5-triiodothyronine
liothyroninum
L-3,5,3'-Triiodothyronine
Triiodothyronine
3,5,3'-Triiodothyronine
L-triiodothyronine
3,5,3'TRIIODOTHYRONINE
Liothyronine
3,5,3'-Triiodo-L-thyronine
liotironina
L-T3
T3
Tertroxin
Tresitope
3,3',5-triiodo-L-thyronine
See more
See less
|
| is conjugate acid of |
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