The Drug Ontology

Last uploaded: December 20, 2024
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Id http://purl.obolibrary.org/obo/CHEBI_17650
http://purl.obolibrary.org/obo/CHEBI_17650
Preferred Name

cortisol
Definitions
A 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses.
Synonyms
Kendall's compound F
Reichstein's substance M
hydrocortisonum
11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione
(11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
4-pregnen-11beta,17alpha,21-triol-3,20-dione
hydrocortisone
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11beta-hydrocortisone
hidrocortisona
17-hydroxycorticosterone
Hydrocortisone
11beta,17,21-trihydroxypregn-4-ene-3,20-dione
Cortisol
cortisol
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Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses.
label
cortisol
prefLabel
cortisol
database_cross_reference
LINCS:LSM-5980
Wikipedia:Hydrocortisone
KEGG:D00088
Patent:US2602769
Beilstein:1354819
Drug_Central:1388
PDBeChem:HCY
KEGG:C00735
CAS:50-23-7
PMID:2268561
PMID:10438974
DrugBank:DB00741
LIPID_MAPS_instance:LMST02030001
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notation
CHEBI:17650
in_subset
inchi
InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
has_related_synonym
Kendall's compound F
Reichstein's substance M
hydrocortisonum
11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione
(11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
4-pregnen-11beta,17alpha,21-triol-3,20-dione
hydrocortisone
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11beta-hydrocortisone
hidrocortisona
17-hydroxycorticosterone
Hydrocortisone
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id
CHEBI:17650
charge
0
has_obo_namespace
chebi_ontology
formula
C21H30O5
has parent hydride
subClassOf
inchikey
JYGXADMDTFJGBT-VWUMJDOOSA-N
mass
362.45990
monoisotopicmass
362.20932
has_alternative_id
CHEBI:58221
CHEBI:24633
CHEBI:14023
CHEBI:3893
type
smiles
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO
has_RxCUI
5492
has role
has_exact_synonym
11beta,17,21-trihydroxypregn-4-ene-3,20-dione
Cortisol
cortisol
has characteristic
alternative label
Kendall's compound F
Reichstein's substance M
hydrocortisonum
11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione
(11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
4-pregnen-11beta,17alpha,21-triol-3,20-dione
hydrocortisone
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11beta-hydrocortisone
hidrocortisona
17-hydroxycorticosterone
Hydrocortisone
11beta,17,21-trihydroxypregn-4-ene-3,20-dione
Cortisol
cortisol
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