Preferred Name

IgE responsiveness, atopic

Synonyms

type I immediate hypersensitivity reaction

IgE responsiveness, atopic

type I hypersensitivity

type 1 hypersensitivity reaction

type I hypersensitivity reaction

type 1 hypersensitivity

IgE, elevated level of

immediate hypersensitivity

IgE response underlying allergic asthma and rhinitis

Immunoglobulin E, basic level of, in serum

atopy, susceptibility to

IGER

IgE, level of

Atopic hypersensitivity

IgE responsiveness, ATOPIC

Definitions

Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue.

ID

http://purl.obolibrary.org/obo/MONDO_0007817

has_exact_synonym

type I immediate hypersensitivity reaction

IgE responsiveness, atopic

type I hypersensitivity

type 1 hypersensitivity reaction

type I hypersensitivity reaction

type 1 hypersensitivity

IgE, elevated level of

immediate hypersensitivity

has_related_synonym

IgE response underlying allergic asthma and rhinitis

Immunoglobulin E, basic level of, in serum

atopy, susceptibility to

IGER

IgE, level of

Atopic hypersensitivity

IgE responsiveness, ATOPIC

IAO_0000233

https://github.com/monarch-initiative/mondo/issues/4521

label

IgE responsiveness, atopic

prefixIRI

MONDO:0007817

prefLabel

IgE responsiveness, atopic

textual definition

Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue.

subClassOf

http://purl.obolibrary.org/obo/MONDO_0004980

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