loading...| Preferred Name |
IgE responsiveness, atopic |
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| Synonyms |
type I immediate hypersensitivity reaction IgE responsiveness, atopic type I hypersensitivity type 1 hypersensitivity reaction type I hypersensitivity reaction type 1 hypersensitivity IgE, elevated level of immediate hypersensitivity IgE response underlying allergic asthma and rhinitis Immunoglobulin E, basic level of, in serum atopy, susceptibility to IGER IgE, level of Atopic hypersensitivity IgE responsiveness, ATOPIC |
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| Definitions |
Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue. |
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| ID |
http://purl.obolibrary.org/obo/MONDO_0007817 |
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| has_exact_synonym |
type I immediate hypersensitivity reaction IgE responsiveness, atopic type I hypersensitivity type 1 hypersensitivity reaction type I hypersensitivity reaction type 1 hypersensitivity IgE, elevated level of immediate hypersensitivity |
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| has_related_synonym |
IgE response underlying allergic asthma and rhinitis Immunoglobulin E, basic level of, in serum atopy, susceptibility to IGER IgE, level of Atopic hypersensitivity IgE responsiveness, ATOPIC |
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| IAO_0000233 | ||
| label |
IgE responsiveness, atopic |
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| prefixIRI |
MONDO:0007817 |
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| prefLabel |
IgE responsiveness, atopic |
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| textual definition |
Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue. |
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| subClassOf |