Digital medicine Outcomes Value Set (DOVeS) Ontology

Last uploaded: December 13, 2023
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Preferred Name

neoplasm of mature B-cells
Synonyms

mature B-cell neoplasms

mature B-cell lymphocytic neoplasm

mature B-cell neoplasm
Definitions

A neoplasm of follicle centre B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001). Editor note: is a non-hodgkin in ONCOTREE
ID

http://purl.obolibrary.org/obo/MONDO_0004949
comment

Editor note: is a non-hodgkin in ONCOTREE
altLabel

mature B-cell neoplasms

mature B-cell lymphocytic neoplasm

mature B-cell neoplasm
definition

A neoplasm of follicle centre B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).

Editor note: is a non-hodgkin in ONCOTREE
has_exact_synonym

mature B-cell lymphocytic neoplasm

mature B-cell neoplasm
has_related_synonym

mature B-cell neoplasms
label

neoplasm of mature B-cells
prefixIRI

MONDO:0004949
prefLabel

neoplasm of mature B-cells
textual definition

A neoplasm of follicle centre B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).
subClassOf

http://purl.obolibrary.org/obo/MONDO_0004095
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