Preferred Name |
estriol |
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Synonyms |
C18H24O3 (1S,10R,11S,13R,14R,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,13,14-triol |
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ID |
http://purl.obolibrary.org/obo/dinto_DB04573 |
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activates | ||
ATCCode |
G03CA04 G03CC06 |
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CASRN |
50-27-1 |
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DBBrand |
trimesta |
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DBSalt |
estriol tripropionate |
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DBSynonym |
(16?,17?)-estra-1,3,5(10)-triene-3,16,17-triol 16alpha-hydroxyestradiol 16?-hydroxyestradiol 16-alpha-hydroxyestradiol oestriol |
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Definition |
A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes. |
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has pharmacological target | ||
InChI |
InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1 |
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InChIKey |
InChIKey=PROQIPRRNZUXQM-ZXXIGWHRSA-N |
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induces | ||
inhibits | ||
is transported by | ||
label |
estriol |
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may interact with |
http://purl.obolibrary.org/obo/dinto_DB00400 http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/dinto_DB00794 http://purl.obolibrary.org/obo/CHEBI_8069 http://purl.obolibrary.org/obo/CHEBI_8772 http://purl.obolibrary.org/obo/CHEBI_8382 |
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prefixIRI |
obo2:dinto_DB04573 |
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prefLabel |
estriol |
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SMILES |
[H][C@@]12C[C@@H](O)[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3 |
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Synonym |
C18H24O3 (1S,10R,11S,13R,14R,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,13,14-triol |
|
xref |
PubChem Substance:46505881 ChemSpider:5553 PharmGKB:PA164769104 PDB:ESL Wikipedia:http://en.wikipedia.org/wiki/Estriol PubChem Compound:5756 ChEBI:27974 |
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subClassOf |