The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	trovafloxacin
Synonyms	7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid C20H15F3N4O3
ID	http://purl.obolibrary.org/obo/dinto_DB00685
ATCCode	J01MA13
CASRN	147059-72-1
DBBrand	trovan
DBSynonym	tvfx trovafloxacin mesylate
Definition	Trovafloxacin (sold as Trovan by Pfizer) is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was withdrawn from the market due to the risk of hepatotoxicity. It had better gram-positive bacterial coverage and less gram-negative coverage than the previous fluoroquinolones. [Wikipedia]
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000496 http://purl.obolibrary.org/obo/OAE_0001285 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000356 http://purl.obolibrary.org/obo/OAE_0000604 http://purl.obolibrary.org/obo/OAE_0000557 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000479 http://purl.obolibrary.org/obo/OAE_0000492 http://purl.obolibrary.org/obo/OAE_0000617 http://purl.obolibrary.org/obo/OAE_0000198 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0000825 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0000900 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0000611 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0001333 http://purl.obolibrary.org/obo/OAE_0001369 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0001013 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000317 http://purl.obolibrary.org/obo/OAE_0000482 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000805 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0001025 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000050 http://purl.obolibrary.org/obo/OAE_0000426 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000608 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000539 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0001026 http://purl.obolibrary.org/obo/OAE_0000287 http://purl.obolibrary.org/obo/OAE_0000690 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000691 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0000687 http://purl.obolibrary.org/obo/OAE_0000517 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0000309 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000494 http://purl.obolibrary.org/obo/OAE_0000510 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000842 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000533 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000968 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000421 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000470 http://purl.obolibrary.org/obo/OAE_0001030 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0001166 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000916 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0000618 http://purl.obolibrary.org/obo/OAE_0001458 http://purl.obolibrary.org/obo/OAE_0000513 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target	http://purl.obolibrary.org/obo/dinto_0551 http://purl.obolibrary.org/obo/dinto_1028
InChI	InChI=1S/C20H15F3N4O3/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24/h1-4,7,10-11,16H,5-6,24H2,(H,29,30)/t10-,11+,16?
InChIKey	InChIKey=WVPSKSLAZQPAKQ-SOSAQKQKSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_0551 http://purl.obolibrary.org/obo/dinto_2751 http://purl.obolibrary.org/obo/dinto_1028
label	trovafloxacin
may interact with	http://purl.obolibrary.org/obo/CHEBI_490877 http://purl.obolibrary.org/obo/CHEBI_17303 http://purl.obolibrary.org/obo/CHEBI_8713 http://purl.obolibrary.org/obo/dinto_DB00893 http://purl.obolibrary.org/obo/dinto_DB00258 http://purl.obolibrary.org/obo/dinto_DB01370 http://purl.obolibrary.org/obo/CHEBI_31794 http://purl.obolibrary.org/obo/dinto_DB00364 http://purl.obolibrary.org/obo/CHEBI_32599 http://purl.obolibrary.org/obo/dinto_DB01593 http://purl.obolibrary.org/obo/dinto_DB00658 http://purl.obolibrary.org/obo/dinto_DB01378 http://purl.obolibrary.org/obo/dinto_DB01164 http://purl.obolibrary.org/obo/dinto_DB00326 http://purl.obolibrary.org/obo/dinto_DB01373 http://purl.obolibrary.org/obo/dinto_DB01592
prefixIRI	obo2:dinto_DB00685
prefLabel	trovafloxacin
SMILES	[H][C@@]12CN(C[C@]1([H])C2N)C1=C(F)C=C2C(=O)C(=CN(C3=C(F)C=C(F)C=C3)C2=N1)C(O)=O
Synonym	7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid C20H15F3N4O3
xref	PubChem Compound:62959 BindingDB:50146361 ChemSpider:56670 Drugs Product Database (DPD):2239191 PubChem Substance:46508751 Drugs.com:http://www.drugs.com/mtm/trovafloxacin.html RxList:http://www.rxlist.com/cgi/generic/trovazit.htm National Drug Code Directory:0049-3890-28 Wikipedia:http://en.wikipedia.org/wiki/Trovafloxacin PharmGKB:PA164749184
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/XCO_0001257	XCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9763	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_9763	PHIPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9763	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_9763	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9763	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9763	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9763	DRON	LOOM
http://purl.jp/bio/4/id/200906045301827270	IOBC	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/96092008	SNOMEDCT	LOOM
http://stirdf.jst.go.jp/id/200907039279626307	IOBC	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026058	PMAPP-PMO	LOOM
http://www.drugbank.ca/drugs/DB00685	FTC	LOOM
http://purl.bioontology.org/ontology/LNC/LP17281-4	LOINC	LOOM
http://purl.bioontology.org/ontology/VANDF/4024108	VANDF	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022113	NDFRT	LOOM
http://purl.bioontology.org/ontology/ATC/J01MA13	ATC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C080163	RH-MESH	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66644	NCIT	LOOM
http://purl.obolibrary.org/obo/ARO_3000664	ARO	LOOM
http://purl.obolibrary.org/obo/NCIT_C66644	BERO	LOOM
https://go.drugbank.com/drugs/DB00685	MDM	LOOM
http://purl.bioontology.org/ontology/RXNORM/115552	RXNORM	LOOM
http://purl.bioontology.org/ontology/NDDF/007320	NDDF	LOOM
http://purl.bioontology.org/ontology/MESH/C080163	MESH	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU011341	LOINC	LOOM
http://purl.bioontology.org/ontology/SNMI/C-557E0	SNMI	LOOM