The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

dextromethorphan

Synonyms

(1R,9R,10R)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2,4,6-triene

C18H25NO

ID

http://purl.obolibrary.org/obo/dinto_DB00514

activates

http://purl.obolibrary.org/obo/dinto_1136

http://purl.obolibrary.org/obo/dinto_2735

AHFScode

48:16.00

48:08.00

ATCCode

R05DA09

blocks

http://purl.obolibrary.org/obo/dinto_3364

http://purl.obolibrary.org/obo/dinto_2747

CASRN

125-71-3

DBBrand

novahistex dm

hold dm

dormethan

benylin dm for children

benylin dm 12 hour

cough-x

methorphan

triaminic dm long lasting for children

benylin pediatric cough suppressant

methorate hydrobromide

calmylin #1

romilar

medicon

benylin dm for children 12 hour

tusilan

vicks 44 cough relief

dormetan

pertussin dm extra strength

benylin dm

balminil dm children

sucrets 4 hour cough suppressant

delsym cough formula

metrorat

benylin adult formula cough suppressant

koffex dm

hihustan m.

cosylan

novahistine dm

canfodion

creo-terpin

robitussin pediatric cough suppressant

diabe-tuss dm syrup

pertussin cs children's strength

antussan

balminil dm

robitussin maximum strength cough suppressant

tussade

delsym

robitussin pediatric

trocal

DBSynonym

dextromethorphan bromide

dextrometorfano [inn-spanish]

d-methorphan

levometorfano [inn-spanish]

levomethorphan [ban:dcf:inn]

dextromethorfan [czech]

delta-methorphan

demorphine

l-methorphan

dextromorphan

dexyromethorphan

levomethorphan

levomethorphane [inn-french]

d-methorphan hydrobromide

demorphan hydrobromide

dextrometorphan

demorphan

destrometerfano [dcit]

levomethorphanum [inn-latin]

dextromethorphan bromhydrate

Definition

The d-isomer of the codeine analog of levorphanol. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. [PubChem]

has pharmacological target

http://purl.obolibrary.org/obo/dinto_3364

http://purl.obolibrary.org/obo/dinto_1136

http://purl.obolibrary.org/obo/dinto_2735

InChI

InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m0/s1

InChIKey

InChIKey=MKXZASYAUGDDCJ-CGTJXYLNSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_1440

http://purl.obolibrary.org/obo/dinto_2714

is metabolised by

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_1956

http://purl.obolibrary.org/obo/dinto_2990

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_0291

http://purl.obolibrary.org/obo/dinto_0293

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0465

http://purl.obolibrary.org/obo/dinto_1221

label

dextromethorphan

may interact with

http://purl.obolibrary.org/obo/dinto_DB01346

http://purl.obolibrary.org/obo/CHEBI_63620

http://purl.obolibrary.org/obo/CHEBI_5118

http://purl.obolibrary.org/obo/CHEBI_70707

http://purl.obolibrary.org/obo/CHEBI_9943

http://purl.obolibrary.org/obo/dinto_DB01341

http://purl.obolibrary.org/obo/CHEBI_32250

http://purl.obolibrary.org/obo/dinto_DB01037

http://purl.obolibrary.org/obo/dinto_DB00752

http://purl.obolibrary.org/obo/dinto_DB06700

http://purl.obolibrary.org/obo/CHEBI_63637

http://purl.obolibrary.org/obo/dinto_DB00780

http://purl.obolibrary.org/obo/CHEBI_10124

http://purl.obolibrary.org/obo/dinto_DB01171

http://purl.obolibrary.org/obo/CHEBI_9654

http://purl.obolibrary.org/obo/CHEBI_28593

http://purl.obolibrary.org/obo/dinto_DB00726

http://purl.obolibrary.org/obo/dinto_DB06273

http://purl.obolibrary.org/obo/dinto_DB00857

http://purl.obolibrary.org/obo/CHEBI_68642

http://purl.obolibrary.org/obo/CHEBI_7936

http://purl.obolibrary.org/obo/dinto_DB01105

http://purl.obolibrary.org/obo/dinto_DB01247

prefixIRI

obo2:dinto_DB00514

prefLabel

dextromethorphan

SMILES

[H][C@@]12CCCC[C@@]11CCN(C)[C@@H]2CC2=C1C=C(OC)C=C2

Synonym

(1R,9R,10R)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2,4,6-triene

C18H25NO

xref

Wikipedia:http://en.wikipedia.org/wiki/Dextromethorphan

Drugs.com:http://www.drugs.com/dextromethorphan.html

Drugs Product Database (DPD):816000

National Drug Code Directory:63824-171-63

PharmGKB:PA449273

ChEBI:4470

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/LNC/LA28643-7 LOINC LOOM
http://purl.bioontology.org/ontology/SNMI/C-88130 SNMI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.132.577.249.200 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387114001 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDDF/004427 NDDF LOOM
http://purl.bioontology.org/ontology/UATC/R05DA09 ATC LOOM
http://www.drugbank.ca/drugs/DB00514 FTC LOOM
http://purl.obolibrary.org/obo/CHEBI_4470 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_4470 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_4470 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_4470 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4470 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4470 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_4470 DIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_4470 HINO LOOM
http://purl.obolibrary.org/obo/CHEBI_4470 NIFSTD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003915 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004183 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.605.497.212 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.723.795.200 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907070908698485 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D003915 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0011816 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.549.686.212 RH-MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005735 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005735 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005735 DMTO LOOM
http://purl.bioontology.org/ontology/LNC/LP16105-6 LOINC LOOM
http://www.co-ode.org/ontologies/galen#Dextromethorphan GALEN LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3830 OCHV LOOM
http://purl.bioontology.org/ontology/VANDF/4018052 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/3289 RXNORM LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005740 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005740 DMTO LOOM
http://purl.bioontology.org/ontology/CSP/4007-0038 CRISP LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146393 NDFRT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62022 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62022 NCIT LOOM
http://purl.jp/bio/4/id/200906042174065480 IOBC LOOM