The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	erythromycin
Synonyms	(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione C37H67NO13
ID	http://purl.obolibrary.org/obo/dinto_DB00199
AHFScode	08:12.12.04 52:04.04 34:00.00
ATCCode	J01FA01 D10AF02 S01AA17
CASRN	114-07-8
DBBrand	pfizer-e erygel erypar torlamicina abomacetin eryc sprinkles eryderm ilotycin e-glades kesso-mycin ak-mycin e-base stiemycin emu ethril 250 benzamycin pak ilocaps erycen indermretcin e-solve 2 propiocine dotycin benzamycin ermycin bristamycin ilosone erythrogran wyamycin s r-p mycin eritrocina theramycin z eryc 125 wemid sansac erythromycin a robimycin erythromid erythro erythromycin b ilotycin gluceptate ery-sol erycette dumotrycin ery-tab erythromast 36 akne-mycin abboticin pantomicina erythro-statin emgel mephamycin aknin erycinum erythroguent eryc erymax erycin e-mycin taimoxin-f erythra-derm
DBSynonym	em erythromycin lactobionate erythromycin stearate erythromycin glucoheptonate erythrocin stearate erythromycin oxime erythromycin ethylsuccinate
Definition	Erythromycin is a macrolide antibiotic produced by Streptomyces erythreus. It inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits; binding inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. Erythromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000198 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000825 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0000913 http://purl.obolibrary.org/obo/OAE_0001333 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000687 http://purl.obolibrary.org/obo/OAE_0000312 http://purl.obolibrary.org/obo/OAE_0000911 http://purl.obolibrary.org/obo/OAE_0001200 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2449 http://purl.obolibrary.org/obo/dinto_2448 http://purl.obolibrary.org/obo/dinto_2857
InChI	InChI=1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1
InChIKey	InChIKey=ULGZDMOVFRHVEP-RWJQBGPGSA-N
induces	http://purl.obolibrary.org/obo/dinto_1440
inhibits	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_1977 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2449 http://purl.obolibrary.org/obo/dinto_2448 http://purl.obolibrary.org/obo/dinto_2857 http://purl.obolibrary.org/obo/dinto_1987 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_2828 http://purl.obolibrary.org/obo/dinto_1956
is metabolised by	http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1956
is transported by	http://purl.obolibrary.org/obo/dinto_1440
label	erythromycin
may interact with	http://purl.obolibrary.org/obo/dinto_DB00683 http://purl.obolibrary.org/obo/CHEBI_8212 http://purl.obolibrary.org/obo/CHEBI_71219 http://purl.obolibrary.org/obo/CHEBI_66903 http://purl.obolibrary.org/obo/CHEBI_32250 http://purl.obolibrary.org/obo/CHEBI_68478 http://purl.obolibrary.org/obo/dinto_DB01303 http://purl.obolibrary.org/obo/CHEBI_9948 http://purl.obolibrary.org/obo/CHEBI_4551 http://purl.obolibrary.org/obo/CHEBI_585948 http://purl.obolibrary.org/obo/dinto_DB00912 http://purl.obolibrary.org/obo/CHEBI_10100 http://purl.obolibrary.org/obo/CHEBI_49668 http://purl.obolibrary.org/obo/CHEBI_66876 http://purl.obolibrary.org/obo/CHEBI_39867 http://purl.obolibrary.org/obo/CHEBI_66901 http://purl.obolibrary.org/obo/dinto_DB00541 http://purl.obolibrary.org/obo/CHEBI_4672 http://purl.obolibrary.org/obo/dinto_DB00243 http://purl.obolibrary.org/obo/CHEBI_3223 http://purl.obolibrary.org/obo/CHEBI_8707 http://purl.obolibrary.org/obo/CHEBI_499361 http://purl.obolibrary.org/obo/CHEBI_156095 http://purl.obolibrary.org/obo/CHEBI_63611 http://purl.obolibrary.org/obo/CHEBI_31401 http://purl.obolibrary.org/obo/dinto_DB01223 http://purl.obolibrary.org/obo/dinto_DB01627 http://purl.obolibrary.org/obo/CHEBI_31547 http://purl.obolibrary.org/obo/dinto_DB06207 http://purl.obolibrary.org/obo/CHEBI_4031 http://purl.obolibrary.org/obo/dinto_DB01394 http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/CHEBI_9150 http://purl.obolibrary.org/obo/CHEBI_584020 http://purl.obolibrary.org/obo/CHEBI_48390 http://purl.obolibrary.org/obo/CHEBI_63622 http://purl.obolibrary.org/obo/dinto_DB00342 http://purl.obolibrary.org/obo/CHEBI_53766 http://purl.obolibrary.org/obo/CHEBI_63632 http://purl.obolibrary.org/obo/CHEBI_3172 http://purl.obolibrary.org/obo/CHEBI_40303 http://purl.obolibrary.org/obo/CHEBI_6780 http://purl.obolibrary.org/obo/CHEBI_133809 http://purl.obolibrary.org/obo/CHEBI_9566 http://purl.obolibrary.org/obo/CHEBI_3181 http://purl.obolibrary.org/obo/CHEBI_3558 http://purl.obolibrary.org/obo/CHEBI_51364 http://purl.obolibrary.org/obo/dinto_DB01167 http://purl.obolibrary.org/obo/dinto_DB00570 http://purl.obolibrary.org/obo/CHEBI_63598 http://purl.obolibrary.org/obo/CHEBI_3766 http://purl.obolibrary.org/obo/CHEBI_47657 http://purl.obolibrary.org/obo/CHEBI_9654 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/dinto_DB06212 http://purl.obolibrary.org/obo/dinto_DB01558 http://purl.obolibrary.org/obo/dinto_DB00365 http://purl.obolibrary.org/obo/CHEBI_32020 http://purl.obolibrary.org/obo/CHEBI_2611 http://purl.obolibrary.org/obo/CHEBI_10119 http://purl.obolibrary.org/obo/CHEBI_4728 http://purl.obolibrary.org/obo/CHEBI_3387 http://purl.obolibrary.org/obo/CHEBI_9635 http://purl.obolibrary.org/obo/CHEBI_3720 http://purl.obolibrary.org/obo/CHEBI_3723 http://purl.obolibrary.org/obo/CHEBI_39548 http://purl.obolibrary.org/obo/CHEBI_480999 http://purl.obolibrary.org/obo/CHEBI_45367 http://purl.obolibrary.org/obo/CHEBI_6888 http://purl.obolibrary.org/obo/CHEBI_9398 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/CHEBI_32315 http://purl.obolibrary.org/obo/CHEBI_45716 http://purl.obolibrary.org/obo/dinto_DB01105 http://purl.obolibrary.org/obo/CHEBI_28593 http://purl.obolibrary.org/obo/CHEBI_9168 http://purl.obolibrary.org/obo/CHEBI_9123 http://purl.obolibrary.org/obo/dinto_DB01118 http://purl.obolibrary.org/obo/CHEBI_9139 http://purl.obolibrary.org/obo/CHEBI_3286 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/dinto_DB00353 http://purl.obolibrary.org/obo/dinto_DB00503 http://purl.obolibrary.org/obo/dinto_DB01369 http://purl.obolibrary.org/obo/CHEBI_49575 http://purl.obolibrary.org/obo/CHEBI_4822 http://purl.obolibrary.org/obo/CHEBI_4657 http://purl.obolibrary.org/obo/CHEBI_2896 http://purl.obolibrary.org/obo/dinto_DB01287 http://purl.obolibrary.org/obo/CHEBI_28177 http://purl.obolibrary.org/obo/CHEBI_50922 http://purl.obolibrary.org/obo/CHEBI_68575 http://purl.obolibrary.org/obo/CHEBI_114785 http://purl.obolibrary.org/obo/CHEBI_28077 http://purl.obolibrary.org/obo/dinto_DB01346 http://purl.obolibrary.org/obo/CHEBI_9674 http://purl.obolibrary.org/obo/dinto_DB06210 http://purl.obolibrary.org/obo/CHEBI_195280 http://purl.obolibrary.org/obo/CHEBI_71272 http://purl.obolibrary.org/obo/dinto_DB01208 http://purl.obolibrary.org/obo/dinto_DB01623 http://purl.obolibrary.org/obo/CHEBI_64318 http://purl.obolibrary.org/obo/CHEBI_4681 http://purl.obolibrary.org/obo/CHEBI_46295 http://purl.obolibrary.org/obo/dinto_DB00976 http://purl.obolibrary.org/obo/CHEBI_45783 http://purl.obolibrary.org/obo/CHEBI_2569 http://purl.obolibrary.org/obo/CHEBI_4562 http://purl.obolibrary.org/obo/CHEBI_5118
prefixIRI	obo2:dinto_DB00199
prefLabel	erythromycin
SMILES	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
Synonym	(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione C37H67NO13
xref	PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/ery1163.shtml PharmGKB:PA449493 RxList:http://www.rxlist.com/cgi/generic/erithrom.htm ChemSpider:12041 PDB:ERY Drugs.com:http://www.drugs.com/cdi/erythromycin-ointment.html Drugs Product Database (DPD):2237041 PubChem Compound:12560 PubChem Substance:46508487 National Drug Code Directory:0168-0215-01 ChEBI:48923 Wikipedia:http://en.wikipedia.org/wiki/Erythromycin
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_48923	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/XCO_0001156	XCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_48923	FYPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_48923	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_48923	PHIPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_48923	CHEBI	LOOM
http://purl.jp/bio/4/id/200906036611157798	IOBC	LOOM
http://purl.bioontology.org/ontology/LNC/LP15115-6	LOINC	LOOM
http://www.co-ode.org/ontologies/galen#Erythromycin	GALEN	LOOM
http://purl.bioontology.org/ontology/ATC/S01AA17	ATC	LOOM
http://www.projecthalo.com/aura#Erythromycin	AURA	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.540.505.250	RH-MESH	LOOM
http://purl.bioontology.org/ontology/RXNORM/4053	RXNORM	LOOM
http://purl.obolibrary.org/obo/MESH_D004917	BERO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372694001	SNOMEDCT	LOOM
http://www.gamuts.net/entity#erythromycin	GAMUTS	LOOM
http://localhost/plosthes.2017-1#7283	PLOSTHES	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039234	PDQ	LOOM
http://stirdf.jst.go.jp/id/200907052174301077	IOBC	LOOM
http://purl.obolibrary.org/obo/HIO_0000282	HIO	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C476	NCIT	LOOM
http://purl.obolibrary.org/obo/ARO_0000006	SCDO	LOOM
http://purl.obolibrary.org/obo/ARO_0000006	ARO	LOOM
https://go.drugbank.com/drugs/DB00199	MDM	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003043	LOINC	LOOM
http://purl.bioontology.org/ontology/VANDF/4017594	VANDF	LOOM
http://purl.bioontology.org/ontology/ATC/D10AF02	ATC	LOOM
http://purl.bioontology.org/ontology/CSP/0200-6292	CRISP	LOOM
http://purl.obolibrary.org/obo/CHEBI_48923	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_48923	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_48923	EUPATH	LOOM
http://purl.obolibrary.org/obo/CHEBI_48923	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_48923	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_48923	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_48923	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_48923	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_48923	MCO	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017179	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/NCIT_C476	BERO	LOOM
http://purl.bioontology.org/ontology/ATC/J01FA01	ATC	LOOM
http://purl.bioontology.org/ontology/MESH/D004917	MESH	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145975	NDFRT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0014806	OCHV	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D004917	RH-MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#4633	OCHV	LOOM
http://purl.obolibrary.org/obo/OMIT_0006149	OMIT	LOOM