Preferred Name |
abciximab |
|
Synonyms |
|
|
ID |
http://purl.obolibrary.org/obo/dinto_DB00054 |
|
AHFScode |
92:00.00 |
|
ATCCode |
B01AC13 |
|
blocks | ||
CASRN |
143653-53-6 |
|
DBBrand |
reopro |
|
DBSynonym |
c7e3 7e3 antibody 7e3 antigpiibiiia |
|
Definition |
Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (?v?3) receptor found on platelets and vessel wall endothelial and smooth muscle cells. |
|
has pharmacological target | ||
label |
abciximab |
|
may interact with |
http://purl.obolibrary.org/obo/CHEBI_9605 http://purl.obolibrary.org/obo/CHEBI_50861 |
|
prefixIRI |
obo2:dinto_DB00054 |
|
prefLabel |
abciximab |
|
related with |
http://purl.obolibrary.org/obo/dinto_3109 http://purl.obolibrary.org/obo/dinto_3105 http://purl.obolibrary.org/obo/dinto_3106 http://purl.obolibrary.org/obo/dinto_3107 http://purl.obolibrary.org/obo/dinto_3078 http://purl.obolibrary.org/obo/dinto_0881 http://purl.obolibrary.org/obo/dinto_3084 http://purl.obolibrary.org/obo/dinto_3112 http://purl.obolibrary.org/obo/dinto_3111 http://purl.obolibrary.org/obo/dinto_3709 |
|
xref |
Drugs.com:http://www.drugs.com/cdi/abciximab.html National Drug Code Directory:0002-7140-01 RxList:http://www.rxlist.com/reopro-drug.htm Wikipedia:http://en.wikipedia.org/wiki/Abciximab PharmGKB:PA448006 Drugs Product Database (DPD):2216973 |
|
subClassOf |