The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	clonazepam
Synonyms	clonazepam 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one 5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one C15H10ClN3O3 clonazepamum 5-(2-chlorophenyl)-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one CLONAZEPAM 5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one 5-(2-chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one 5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
ID	http://purl.obolibrary.org/obo/CHEBI_3756
AHFScode	28:12.08
altId	CHEBI:102465
ATCCode	N03AE01
CASRN	1622-61-3
DBBrand	cloazepam iktorivil antelepsin klonopin rapidly disintegrating rivotril antilepsin landsen klonopin clonopin
DBname	clonazepam
DBSynonym	clonazepamum chlonazepam
Definition	1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
has effect	http://purl.obolibrary.org/obo/OAE_0000599 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000356 http://purl.obolibrary.org/obo/OAE_0000604 http://purl.obolibrary.org/obo/OAE_0000557 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000479 http://purl.obolibrary.org/obo/OAE_0000492 http://purl.obolibrary.org/obo/OAE_0000267 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000493 http://purl.obolibrary.org/obo/OAE_0001167 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0001489 http://purl.obolibrary.org/obo/OAE_0000611 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0001369 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000545 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000205 http://purl.obolibrary.org/obo/OAE_0001268 http://purl.obolibrary.org/obo/OAE_0000317 http://purl.obolibrary.org/obo/OAE_0000482 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0000250 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0001339 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000103 http://purl.obolibrary.org/obo/OAE_0000612 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001300 http://purl.obolibrary.org/obo/OAE_0000517 http://purl.obolibrary.org/obo/OAE_0001105 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0001461 http://purl.obolibrary.org/obo/OAE_0000312 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0000526 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000842 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000473 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000968 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0001403 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000898 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0001336 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000491 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0001147 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001001 http://purl.obolibrary.org/obo/OAE_0000881 http://purl.obolibrary.org/obo/OAE_0000242 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0000466 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0001035 http://purl.obolibrary.org/obo/OAE_0000766 http://purl.obolibrary.org/obo/OAE_0001458 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000350 http://purl.obolibrary.org/obo/OAE_0000304
has pharmacological target	http://purl.obolibrary.org/obo/dinto_0016 http://purl.obolibrary.org/obo/dinto_0630 http://purl.obolibrary.org/obo/dinto_2875 http://purl.obolibrary.org/obo/dinto_0045 http://purl.obolibrary.org/obo/dinto_0043 http://purl.obolibrary.org/obo/dinto_0044 http://purl.obolibrary.org/obo/dinto_0111 http://purl.obolibrary.org/obo/dinto_0114 http://purl.obolibrary.org/obo/dinto_2853 http://purl.obolibrary.org/obo/dinto_1453 http://purl.obolibrary.org/obo/dinto_1457 http://purl.obolibrary.org/obo/dinto_0109 http://purl.obolibrary.org/obo/dinto_0107 http://purl.obolibrary.org/obo/dinto_0199 http://purl.obolibrary.org/obo/dinto_0038 http://purl.obolibrary.org/obo/dinto_3062 http://purl.obolibrary.org/obo/dinto_1948 http://purl.obolibrary.org/obo/dinto_0159
has role	http://purl.obolibrary.org/obo/CHEBI_50268 http://purl.obolibrary.org/obo/CHEBI_35474 http://purl.obolibrary.org/obo/CHEBI_35623
InChI	InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20)
InChIKey	InChIKey=DGBIGWXXNGSACT-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_0293
is metabolised by	http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_2047
label	clonazepam
may interact with	http://purl.obolibrary.org/obo/dinto_DB00224 http://purl.obolibrary.org/obo/dinto_DB00196 http://purl.obolibrary.org/obo/CHEBI_3699 http://purl.obolibrary.org/obo/dinto_DB01323 http://purl.obolibrary.org/obo/dinto_DB01322 http://purl.obolibrary.org/obo/dinto_DB01167 http://purl.obolibrary.org/obo/CHEBI_3766 http://purl.obolibrary.org/obo/CHEBI_63621 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/dinto_DB00427 http://purl.obolibrary.org/obo/CHEBI_63628 http://purl.obolibrary.org/obo/CHEBI_7772 http://purl.obolibrary.org/obo/dinto_DB00503 http://purl.obolibrary.org/obo/CHEBI_63638 http://purl.obolibrary.org/obo/dinto_DB01026 http://purl.obolibrary.org/obo/dinto_DB00220 http://purl.obolibrary.org/obo/dinto_DB00976
prefixIRI	obo2:CHEBI_3756
prefLabel	clonazepam
related with	http://purl.obolibrary.org/obo/dinto_0016 http://purl.obolibrary.org/obo/dinto_0630 http://purl.obolibrary.org/obo/dinto_2875 http://purl.obolibrary.org/obo/dinto_0045 http://purl.obolibrary.org/obo/dinto_0043 http://purl.obolibrary.org/obo/dinto_0044 http://purl.obolibrary.org/obo/dinto_0111 http://purl.obolibrary.org/obo/dinto_0114 http://purl.obolibrary.org/obo/dinto_2745 http://purl.obolibrary.org/obo/dinto_2853 http://purl.obolibrary.org/obo/dinto_1453 http://purl.obolibrary.org/obo/dinto_1457 http://purl.obolibrary.org/obo/dinto_0109 http://purl.obolibrary.org/obo/dinto_0107 http://purl.obolibrary.org/obo/dinto_0199 http://purl.obolibrary.org/obo/dinto_0038 http://purl.obolibrary.org/obo/dinto_3062 http://purl.obolibrary.org/obo/dinto_1948 http://purl.obolibrary.org/obo/dinto_0217 http://purl.obolibrary.org/obo/dinto_0159
SMILES	[O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1 [O-][N+](=O)C1=CC2=C(NC(=O)CN=C2C2=CC=CC=C2Cl)C=C1
Synonym	clonazepam 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one 5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one C15H10ClN3O3 clonazepamum 5-(2-chlorophenyl)-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one CLONAZEPAM 5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one 5-(2-chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one 5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
xref	Patent:US3335181 Drugs.com:http://www.drugs.com/clonazepam.html PubChem Substance:46507677 BindingDB:50019213 National Drug Code Directory:0004-0068-01 PubChem Compound:2802 PharmGKB:PA449050 Wikipedia:http://en.wikipedia.org/wiki/Clonazepam ChEMBL:12213069 Patent:US3116203 ChEBI:3756 KEGG DRUG:D00280 Patent:US3121076 Drugs Product Database (DPD):2242078 Beilstein:759557 ChEMBL:10633040 RxList:http://www.rxlist.com/cgi/generic/clonaz.htm ChemSpider:2700 Wikipedia:Clonazepam DrugBank:DB01068 CASRN:1622-61-3 ChEMBL:12873507
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_3756	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3756	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3756	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3756	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3756	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3756	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3756	CHEBI	LOOM
http://www.case.edu/EpilepsyOntology.owl#Clonazepam	EPSO	LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Clonazepam	STMSO	LOOM
http://purl.bioontology.org/ontology/RXNORM/2598	RXNORM	LOOM
https://go.drugbank.com/drugs/DB01068	MDM	LOOM
http://purl.bioontology.org/ontology/RCD/x02Lk	RCD	LOOM
http://purl.bioontology.org/ontology/VANDF/4017791	VANDF	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass6be0bf4f_767a_4254_9f97_460409d0d1a3	WWECA	LOOM
http://purl.bioontology.org/ontology/MESH/D002998	MESH	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU066196	LOINC	LOOM
http://purl.bioontology.org/ontology/ATC/N03AE01	ATC	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Clonazepam	APAONTO	LOOM
http://purl.bioontology.org/ontology/LNC/LP16086-8	LOINC	LOOM
http://purl.obolibrary.org/obo/CHEBI_3756	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3756	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3756	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3756	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_3756	DRON	LOOM
http://stirdf.jst.go.jp/id/200907079739139274	IOBC	LOOM
http://scai.fraunhofer.de/AlzheimerOntology#Clonazepam	ADO	LOOM
http://purl.bioontology.org/ontology/NDDF/001635	NDDF	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3055	OCHV	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassc484c91a_e97e_4a4e_b057_8cb67d9f463a	WWECA	LOOM
http://www.limics.fr/ontologies/ontoparonmed#Rivotril	ONTOPARON	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017576	PMAPP-PMO	LOOM
http://doe-generated-ontology.com/OntoAD#C0009011	ONTOAD	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002998	RH-MESH	LOOM
http://www.drugbank.ca/drugs/DB01068	FTC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0009011	OCHV	LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#clonazepam	SDO	LOOM
http://purl.jp/bio/4/id/200906076591835400	IOBC	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387383007	SNOMEDCT	LOOM
http://purl.obolibrary.org/obo/NCIT_C28935	BERO	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146152	NDFRT	LOOM
http://www.co-ode.org/ontologies/galen#Clonazepam	GALEN	LOOM
http://purl.bioontology.org/ontology/CSP/0314-4549	CRISP	LOOM
http://scai.fraunhofer.de/MSOntology#clonazepam	MSO	LOOM
http://purl.obolibrary.org/obo/OMIT_0004310	OMIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.079.080.070.150	RH-MESH	LOOM
http://purl.bioontology.org/ontology/SNMI/C-64510	SNMI	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass3546c8a6_b0ee_410a_bfd8_477e3e3935c9	WWECA	LOOM
http://purl.obolibrary.org/obo/MESH_D002998	BERO	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060460	LOINC	LOOM
http://scai.fraunhofer.de/MSOntology#Clonazepam	MSO	LOOM
http://www.case.edu/EpSO.owl#Clonazepam	MEPO	LOOM
http://www.semanticweb.org/ftuha/ontologies/2021/5/FRMO-01untitled-ontology-175/Clonazepam	FRMO	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28935	NCIT	LOOM