The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	amitriptyline
Synonyms	5-(gamma-dimethylaminopropylidene)-5H-dibenzo[a,d][1,4]cycloheptadiene Amitriptyline 5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene C20H23N 10,11-dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-Delta(5),gamma-propylamine 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine Amitriptylin 10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine 5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene dimethyl({3-[(2Z)-tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene]propyl})amine 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
ID	http://purl.obolibrary.org/obo/CHEBI_2666
activates	http://purl.obolibrary.org/obo/dinto_0760 http://purl.obolibrary.org/obo/dinto_1246 http://purl.obolibrary.org/obo/dinto_3960 http://purl.obolibrary.org/obo/dinto_2042
AHFScode	28:16.04.28
ATCCode	N06AA09
blocks	http://purl.obolibrary.org/obo/dinto_3182 http://purl.obolibrary.org/obo/dinto_3475 http://purl.obolibrary.org/obo/dinto_1005 http://purl.obolibrary.org/obo/dinto_0703 http://purl.obolibrary.org/obo/dinto_3887 http://purl.obolibrary.org/obo/dinto_1071 http://purl.obolibrary.org/obo/dinto_0392 http://purl.obolibrary.org/obo/dinto_0234 http://purl.obolibrary.org/obo/dinto_2097 http://purl.obolibrary.org/obo/dinto_1135
CASRN	50-48-6
DBBrand	lantron damilen elanil amitid adepril sylvemid sarotex triptilin horizon proheptadiene laroxil saroten elavil triptanol tryptanol redomex laroxyl amitril adepress triptisol flavyl lentizol endep tryptizol seroten damilan
DBname	amitriptyline
DBSalt	amitriptyline hydrochloride
DBSynonym	amitryptiline amitriptylin amytriptiline amitriprolidine amitryptyline
Definition	A tricyclic antidepressant that has formula C20H23N.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000785 http://purl.obolibrary.org/obo/OAE_0000589 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000596 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0001489 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0001069 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000608 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0001026 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000642 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001105 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0001068 http://purl.obolibrary.org/obo/OAE_0000309 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000842 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000752 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000898 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000491 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001001 http://purl.obolibrary.org/obo/OAE_0000881 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0000534
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2714 http://purl.obolibrary.org/obo/dinto_0392 http://purl.obolibrary.org/obo/dinto_0068
has role	http://purl.obolibrary.org/obo/CHEBI_35640
InChI	InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
InChIKey	InChIKey=KRMDCWKBEZIMAB-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_0058 http://purl.obolibrary.org/obo/dinto_2714 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_4068 http://purl.obolibrary.org/obo/dinto_2849 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_0068 http://purl.obolibrary.org/obo/dinto_0062 http://purl.obolibrary.org/obo/dinto_1221
is metabolised by	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0465
is transported by	http://purl.obolibrary.org/obo/dinto_1440
label	amitriptyline
may interact with	http://purl.obolibrary.org/obo/CHEBI_32250 http://purl.obolibrary.org/obo/CHEBI_102524 http://purl.obolibrary.org/obo/CHEBI_9943 http://purl.obolibrary.org/obo/CHEBI_2549 http://purl.obolibrary.org/obo/CHEBI_28918 http://purl.obolibrary.org/obo/CHEBI_8093 http://purl.obolibrary.org/obo/CHEBI_37924 http://purl.obolibrary.org/obo/CHEBI_4670 http://purl.obolibrary.org/obo/dinto_DB00723 http://purl.obolibrary.org/obo/dinto_DB00196 http://purl.obolibrary.org/obo/dinto_DB00476 http://purl.obolibrary.org/obo/CHEBI_156095 http://purl.obolibrary.org/obo/CHEBI_42944 http://purl.obolibrary.org/obo/dinto_DB00209 http://purl.obolibrary.org/obo/dinto_DB01364 http://purl.obolibrary.org/obo/dinto_DB01064 http://purl.obolibrary.org/obo/dinto_DB00857 http://purl.obolibrary.org/obo/CHEBI_8874 http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/CHEBI_149226 http://purl.obolibrary.org/obo/CHEBI_53289 http://purl.obolibrary.org/obo/dinto_DB00342 http://purl.obolibrary.org/obo/dinto_DB01291 http://purl.obolibrary.org/obo/CHEBI_3699 http://purl.obolibrary.org/obo/CHEBI_6780 http://purl.obolibrary.org/obo/CHEBI_9566 http://purl.obolibrary.org/obo/CHEBI_51364 http://purl.obolibrary.org/obo/dinto_DB01366 http://purl.obolibrary.org/obo/CHEBI_6794 http://purl.obolibrary.org/obo/dinto_DB06704 http://purl.obolibrary.org/obo/CHEBI_18243 http://purl.obolibrary.org/obo/dinto_DB00780 http://purl.obolibrary.org/obo/CHEBI_9449 http://purl.obolibrary.org/obo/CHEBI_9654 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/dinto_DB00237 http://purl.obolibrary.org/obo/dinto_DB00427 http://purl.obolibrary.org/obo/dinto_DB00365 http://purl.obolibrary.org/obo/CHEBI_10119 http://purl.obolibrary.org/obo/CHEBI_5138 http://purl.obolibrary.org/obo/CHEBI_3387 http://purl.obolibrary.org/obo/CHEBI_9635 http://purl.obolibrary.org/obo/CHEBI_51209 http://purl.obolibrary.org/obo/CHEBI_3720 http://purl.obolibrary.org/obo/dinto_DB01363 http://purl.obolibrary.org/obo/dinto_DB00397 http://purl.obolibrary.org/obo/CHEBI_27796 http://purl.obolibrary.org/obo/CHEBI_45367 http://purl.obolibrary.org/obo/dinto_DB01247 http://purl.obolibrary.org/obo/dinto_DB00752 http://purl.obolibrary.org/obo/CHEBI_45716 http://purl.obolibrary.org/obo/dinto_DB00382 http://purl.obolibrary.org/obo/dinto_DB01171 http://purl.obolibrary.org/obo/CHEBI_5557 http://purl.obolibrary.org/obo/dinto_DB01365 http://purl.obolibrary.org/obo/dinto_DB01105 http://purl.obolibrary.org/obo/CHEBI_28593 http://purl.obolibrary.org/obo/CHEBI_70707 http://purl.obolibrary.org/obo/dinto_DB00488 http://purl.obolibrary.org/obo/CHEBI_63620 http://purl.obolibrary.org/obo/dinto_DB00503 http://purl.obolibrary.org/obo/CHEBI_18357 http://purl.obolibrary.org/obo/CHEBI_10124 http://purl.obolibrary.org/obo/CHEBI_46631 http://purl.obolibrary.org/obo/dinto_DB01026 http://purl.obolibrary.org/obo/CHEBI_68575 http://purl.obolibrary.org/obo/CHEBI_28077 http://purl.obolibrary.org/obo/dinto_DB01346 http://purl.obolibrary.org/obo/CHEBI_195280 http://purl.obolibrary.org/obo/dinto_DB00816 http://purl.obolibrary.org/obo/dinto_DB01208 http://purl.obolibrary.org/obo/dinto_DB01341 http://purl.obolibrary.org/obo/dinto_DB01623 http://purl.obolibrary.org/obo/CHEBI_5118 http://purl.obolibrary.org/obo/dinto_DB06700
prefixIRI	obo2:CHEBI_2666
prefLabel	amitriptyline
related with	http://purl.obolibrary.org/obo/dinto_1166 http://purl.obolibrary.org/obo/dinto_3582 http://purl.obolibrary.org/obo/dinto_0217
SMILES	CN(C)CCC=C1c2ccccc2CCc2ccccc12 CN(C)CCC=C1C2=CC=CC=C2CCC2=CC=CC=C12
Synonym	5-(gamma-dimethylaminopropylidene)-5H-dibenzo[a,d][1,4]cycloheptadiene Amitriptyline 5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene C20H23N 10,11-dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-Delta(5),gamma-propylamine 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine Amitriptylin 10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine 5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene dimethyl({3-[(2Z)-tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene]propyl})amine 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
xref	IUPHAR:200 PubChem Compound:2160 Wikipedia:Amitriptyline PubChem Substance:46508798 DrugBank:DB00321 NIST Chemistry WebBook:50-48-6 Beilstein:2217885 RxList:http://www.rxlist.com/cgi/generic/amitrip.htm Drugs Product Database (DPD):654515 Guide To Pharmacology:200 ChEBI:2666 ChEMBL:127072 CASRN:50-48-6 PharmGKB:PA448385 Wikipedia:http://en.wikipedia.org/wiki/Amitriptyline Drugs.com:http://www.drugs.com/amitriptyline.html National Drug Code Directory:53489-104-07 KEGG COMPOUND:C06824 ChemSpider:2075
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_2666	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2666	HOIP	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2666	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2666	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2666	COVID-19	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2666	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2666	TXPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2666	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2666	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2666	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2666	ODNAE	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2666	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2666	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_2666	CHEBI	LOOM
http://www.case.edu/EpilepsyOntology.owl#Amitriptyline	EPSO	LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00643	COID	LOOM
https://go.drugbank.com/drugs/DB00321	MDM	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#1027	OCHV	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass21fec350_8b7f_44cc_bd43_db0646190943	WWECA	LOOM
http://scai.fraunhofer.de/AlzheimerOntology#amitriptyline	ADO	LOOM
http://www.case.edu/EpSO.owl#Amitriptyline	MEPO	LOOM
http://www.drugbank.ca/drugs/DB00321	FTC	LOOM
http://www.limics.fr/ontologies/ontoparonmed#Laroxyl	ONTOPARON	LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Amitriptyline	STMSO	LOOM
http://purl.bioontology.org/ontology/MESH/D000639	MESH	LOOM
http://purl.jp/bio/4/id/200906000783681540	IOBC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62005	NCIT	LOOM
http://purl.bioontology.org/ontology/VANDF/4019607	VANDF	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.847.181.384.100	RH-MESH	LOOM
http://purl.obolibrary.org/obo/MESH_D000639	BERO	LOOM
http://purl.bioontology.org/ontology/ATC/N06AA09	ATC	LOOM
http://purl.obolibrary.org/obo/ARO_3007336	ARO	LOOM
http://purl.obolibrary.org/obo/OMIT_0002055	OMIT	LOOM
http://purl.obolibrary.org/obo/NCIT_C62005	BERO	LOOM
http://purl.obolibrary.org/obo/NCIT_C62005	SCDO	LOOM
http://www.co-ode.org/ontologies/galen#Amitriptyline	GALEN	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372726002	SNOMEDCT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0002600	OCHV	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Amitriptyline	APAONTO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.181.384.100	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D000639	RH-MESH	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016899	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/RCD/x01Aw	RCD	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147702	NDFRT	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004907	LOINC	LOOM
http://purl.bioontology.org/ontology/CSP/0780-6741	CRISP	LOOM
http://purl.bioontology.org/ontology/NDDF/004600	NDDF	LOOM
http://bmi.utah.edu/ontologies/peontology/C0002600	RAO	LOOM
http://purl.bioontology.org/ontology/RXNORM/704	RXNORM	LOOM
http://stirdf.jst.go.jp/id/200907030405814109	IOBC	LOOM
http://purl.bioontology.org/ontology/SNMI/C-62250	SNMI	LOOM
http://scai.fraunhofer.de/MSOntology#Amitriptyline	MSO	LOOM
http://www.gamuts.net/entity#amitriptyline	GAMUTS	LOOM
http://purl.bioontology.org/ontology/LNC/LP14983-8	LOINC	LOOM
http://purl.obolibrary.org/obo/CHEBI_2666	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2666	COVID-19	LOOM
http://purl.obolibrary.org/obo/CHEBI_2666	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2666	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2666	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_2666	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_2666	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_2666	ODNAE	LOOM