The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Id http://purl.obolibrary.org/obo/dinto_DB08834
http://purl.obolibrary.org/obo/dinto_DB08834
Preferred Name

tauroursodeoxycholic acid
Synonyms
2-{4-[(1S,2S,5R,7S,9S,10R,11S,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0?,?.0??,??]heptadecan-14-yl]pentanamido}ethane-1-sulfonic acid
C26H45NO6S
Type http://www.w3.org/2002/07/owl#Class

All Properties

prefLabel
tauroursodeoxycholic acid
label
tauroursodeoxycholic acid
DBSynonym
tauroursodeoxycholate
tudca
Definition
Tauroursodeoxycholic acid is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans. Tauroursodeoxycholic acid, on the other hand, is produced abundantly in bears and has been used for centuries as a natural remedy in some Asian countries. It is approved in Italy and Turkey for the treatment of cholesterol gallstones and is an investigational drug in China, Unites States, and Italy. Tauroursodeoxycholic acid is being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis. The only completed clinical trial thus far is a phase III clinical trial comparing tauroursodeoxycholic acid and ursofalk in PBC adult patients, but as of June 2013 no results of this trial have been published.
induces
type
InChIKey
InChIKey=BHTRKEVKTKCXOH-CNHNFURNNA-N
Synonym
2-{4-[(1S,2S,5R,7S,9S,10R,11S,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0?,?.0??,??]heptadecan-14-yl]pentanamido}ethane-1-sulfonic acid
C26H45NO6S
xref
Drugs.com:http://www.drugs.com/international/tauroursodeoxycholic-acid.html
Wikipedia:http://en.wikipedia.org/wiki/Tauroursodeoxycholic_acid
CASRN
14605-22-2
prefixIRI
obo2:dinto_DB08834
related with
SMILES
[H][C@@]12CCC(C(C)CCC(=O)NCCS(O)(=O)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@@H](O)C[C@]2([H])C[C@H](O)CC[C@]12C
InChI
InChI=1/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16?,17-,18+,19?,20-,21-,22-,24-,25-,26+/s2
DBBrand
tauro
taurolite
subClassOf
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