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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB06800
http://purl.obolibrary.org/obo/dinto_DB06800
|
|---|---|
| Preferred Name | methylnaltrexone |
| Synonyms |
(1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-4-methyl-14-oxo-12-oxa-4-azapentacyclo[9.6.1.0?,??.0?,??.0?,??]octadeca-7,9,11(18)-trien-4-ium
C21H26NO4
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | methylnaltrexone
|
|---|---|
| label | methylnaltrexone
|
| DBSynonym |
mntx
n-methylnaltrexone bromide
|
| ATCCode | A06AH01
|
| Definition | Methylnaltrexone is a pheriphally-acting ?-opioid antagonists that acts on the gastrointestinal tract to decrease opioid-induced constipation without producing analgesic effects or withdrawal symptoms. It is also a weak CYP2D6 inhibitor. FDA approved in 2008.
|
| has effect |
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|
| DBSalt | methylnaltrexone bromide
|
| has pharmacological target | |
| inhibits | |
| type | |
| InChIKey | InChIKey=JVLBPIPGETUEET-GAAHOAFPSA-O
|
| blocks | |
| Synonym | (1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-4-methyl-14-oxo-12-oxa-4-azapentacyclo[9.6.1.0?,??.0?,??.0?,??]octadeca-7,9,11(18)-trien-4-ium
C21H26NO4
|
| xref |
National Drug Code Directory:0008-1225-10
Drugs.com:http://www.drugs.com/cdi/methylnaltrexone.html
Wikipedia:http://en.wikipedia.org/wiki/Methylnaltrexone
RxList:http://www.rxlist.com/relistor-drug.htm
|
| CASRN | 73232-52-7
|
| prefixIRI | obo2:dinto_DB06800
|
| SMILES | [H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CC[N+](C)(CC3CC3)[C@]([H])(C4)[C@]1(O)CCC2=O
|
| InChI | InChI=1S/C21H25NO4/c1-22(11-12-2-3-12)9-8-20-17-13-4-5-14(23)18(17)26-19(20)15(24)6-7-21(20,25)16(22)10-13/h4-5,12,16,19,25H,2-3,6-11H2,1H3/p+1/t16-,19+,20+,21-,22?/m1/s1
|
| DBBrand | relistor
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |