loading...| Preferred Name |
aprotinin |
|
| Synonyms |
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|
| ID |
http://purl.obolibrary.org/obo/dinto_DB06692 |
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| AHFScode |
20:28.16 |
|
| ATCCode |
B02AB01 |
|
| CASRN |
9087-70-1 |
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| DBBrand |
trasylol |
|
| DBSynonym |
bovine pancreatic trypsin inhibitor bpti iniprol trazinin bayer a 128 |
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| Definition |
Aprotinin, also known as bovine pancreatic trypsin inhibitor, BPTI (Trasylol, Bayer) is a protein, that is used as medication administered by injection to reduce bleeding during complex surgery, such as heart and liver surgery. Its main effect is the slowing down of fibrinolysis, the process that leads to the breakdown of blood clots. The aim in its use is to decrease the need for blood transfusions during surgery, as well as end-organ damage due to hypotension (low blood pressure) as a result of marked blood loss. The drug was temporarily withdrawn worldwide in 2007 after studies suggested that its use increased the risk of complications or death; after this was confirmed by follow-up studies, Trasylol was entirely and permanently withdrawn in May 2008, except - at least for the time being - for very restricted research use. [Wikipedia] |
|
| label |
aprotinin |
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| may interact with |
http://purl.obolibrary.org/obo/dinto_DB00013 http://purl.obolibrary.org/obo/dinto_DB00031 |
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| prefixIRI |
obo2:dinto_DB06692 |
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| prefLabel |
aprotinin |
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| related with |
http://purl.obolibrary.org/obo/dinto_2148 http://purl.obolibrary.org/obo/dinto_0295 |
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| xref |
PharmGKB:PA448472 Drugs Product Database (DPD):2186845 Drugs.com:http://www.drugs.com/cdi/aprotinin.html National Drug Code Directory:0026-8196-36 Wikipedia:http://en.wikipedia.org/wiki/Aprotinin |
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| subClassOf |