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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB06287
http://purl.obolibrary.org/obo/dinto_DB06287
|
|---|---|
| Preferred Name | temsirolimus |
| Synonyms |
(1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,18R,19R,21R,23S,30S,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.0^{4,9}]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate
C56H87NO16
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | temsirolimus
|
|---|---|
| label | temsirolimus
|
| DBSynonym | cci-779
|
| ATCCode | L01XE09
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| Definition | Temsirolimus is an intravenous drug for the treatment of renal cell carcinoma (RCC), developed by Wyeth Pharmaceuticals and approved by the FDA in late May 2007, and was also approved by the European Medicines Agency (EMEA) on November 2007. It is a derivative of sirolimus and is sold as Torisel.
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| has effect |
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| has pharmacological target | |
| inhibits | |
| type | |
| InChIKey | InChIKey=CBPNZQVSJQDFBE-FUXHJELOSA-N
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| is metabolised by | |
| AHFScode | 10:00
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| Synonym | (1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,18R,19R,21R,23S,30S,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.0^{4,9}]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate
C56H87NO16
|
| xref |
Wikipedia:http://en.wikipedia.org/wiki/Temsirolimus
ChemSpider:21468899
PubChem Compound:23724530
PubChem Substance:99443243
RxList:http://www.rxlist.com/cgi/generic/torisel.htm
PharmGKB:PA164746890
Drugs.com:http://www.drugs.com/cdi/temsirolimus.html
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| CASRN | 162635-04-3
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| prefixIRI | obo2:dinto_DB06287
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| is transported by | |
| SMILES | OCC(C)(CO)C(=O)O[C@@H]1CC[C@@H](C[C@@H](C)[C@]2([H])CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@@H](OC)C[C@]3([H])CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)C[C@H]1OC
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| may interact with |
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| InChI | InChI=1S/C56H87NO16/c1-33-17-13-12-14-18-34(2)45(68-9)29-41-22-20-39(7)56(67,73-41)51(63)52(64)57-24-16-15-19-42(57)53(65)71-46(30-43(60)35(3)26-38(6)49(62)50(70-11)48(61)37(5)25-33)36(4)27-40-21-23-44(47(28-40)69-10)72-54(66)55(8,31-58)32-59/h12-14,17-18,26,33,35-37,39-42,44-47,49-50,58-59,62,67H,15-16,19-25,27-32H2,1-11H3/b14-12+,17-13+,34-18+,38-26+/t33-,35-,36-,37-,39-,40+,41+,42+,44-,45+,46+,47-,49-,50+,56-/m1/s1
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| DBBrand | torisel
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| subClassOf |
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