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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB05013
http://purl.obolibrary.org/obo/dinto_DB05013
|
|---|---|
| Preferred Name | ingenol mebutate |
| Synonyms |
C25H34O6
(1S,4S,5S,6R,9S,10R,12R,14R)-5,6-dihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0^{1,5}.0^{10,12}]pentadeca-2,7-dien-4-yl (2Z)-2-methylbut-2-enoate
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | ingenol mebutate
|
|---|---|
| label | ingenol mebutate
|
| DBSynonym |
ingenol 3-angelate
3-ingenyl angelate
pep005
ingenol mebutate
|
| ATCCode | D06BX02
|
| Definition | Ingenol mebutate was approved by the FDA in January 2012, and it is marketed under the name Picato?. Picato gel is indicated for the topical treatment of actinic keratosis. Before approval, ingenol mebutate was called PEP005 as an investigational drug. PEP005 is a selective small molecule activator of protein kinase C (PKC) extracted from the plant Euphorbia peplus, whose sap has been used as a traditional medicine for the treatment of skin conditions including warts and cancer. PEP005 also has potent anti-leukemic effects, inducing apoptosis in myeloid leukemia cell lines and primary AML cells at nanomolar concentrations.
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| type | |
| InChIKey | InChIKey=VDJHFHXMUKFKET-WDUFCVPESA-N
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| AHFScode | 84:92
|
| Synonym | C25H34O6
(1S,4S,5S,6R,9S,10R,12R,14R)-5,6-dihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0^{1,5}.0^{10,12}]pentadeca-2,7-dien-4-yl (2Z)-2-methylbut-2-enoate
|
| xref |
RxList:http://www.rxlist.com/picato-drug.htm
PubChem Substance:12015710
ChemSpider:5293863
PubChem Compound:6918670
Wikipedia:http://en.wikipedia.org/wiki/Ingenol_mebutate
National Drug Code Directory:50222-503-47
Drugs.com:http://www.drugs.com/ppa/ingenol-mebutate.html
ChEBI:66913
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| CASRN | 75567-37-2
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| prefixIRI | obo2:dinto_DB05013
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| related with | |
| SMILES | OCC1=C[C@]2([H])C(=O)[C@]3(C=C(C)[C@H](OC(=O)C(\C)=C/C)[C@@]3(O)[C@@H]1O)[C@H](C)C[C@@]1([H])C(C)(C)[C@@]21[H]
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| InChI | InChI=1S/C25H34O6/c1-7-12(2)22(29)31-21-13(3)10-24-14(4)8-17-18(23(17,5)6)16(20(24)28)9-15(11-26)19(27)25(21,24)30/h7,9-10,14,16-19,21,26-27,30H,8,11H2,1-6H3/b12-7-/t14-,16+,17-,18+,19-,21+,24+,25+/m1/s1
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| DBBrand | picato gel
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| subClassOf |
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