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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB04865
http://purl.obolibrary.org/obo/dinto_DB04865
|
|---|---|
| Preferred Name | homoharringtonine |
| Synonyms |
(2R,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.0^{2,6}.0^{6,10}.0^{15,19}]icosa-1(13),4,14,19-tetraen-3-yl 1-methyl 3-hydroxy-3-(4-hydroxy-4-methylpentyl)butanedioate
C29H39NO9
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | homoharringtonine
|
|---|---|
| label | homoharringtonine
|
| DBSynonym |
myelostat
omacetaxine mepesuccinate
cephalotaxus alkaloid
hht
cgx-635
nsc-141633
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|
| ATCCode | L01XX40
|
| Definition | Homoharringtonine, AKA HHT or omacetaxine mepesuccinate, is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Homoharringtonine is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, homoharringtonine received Orphan Drug designation from the EMEA for the treatment of chronic myeloid leukemia (CML). Then in March 2006, homoharringtonine received Orphan Drug status from the FDA for the treatment of CML. In November 2006, homoharringtonine, for the treatment of CML, was granted Fast Track designation by the FDA. Most recently, in October 2012, homoharringtonine was marketed under the brand name Synribo? and FDA approved for patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.
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| has pharmacological target | |
| type | |
| InChIKey | InChIKey=HYFHYPWGAURHIV-ZEDNPHJLSA-N
|
| blocks | |
| Synonym | (2R,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.0^{2,6}.0^{6,10}.0^{15,19}]icosa-1(13),4,14,19-tetraen-3-yl 1-methyl 3-hydroxy-3-(4-hydroxy-4-methylpentyl)butanedioate
C29H39NO9
|
| xref |
RxList:http://www.rxlist.com/synribo-drug.htm
National Drug Code Directory:63459-177-14
PubChem Compound:72332
ChEBI:71019
ChemSpider:65276
PubChem Substance:11075063
Wikipedia:http://en.wikipedia.org/wiki/Omacetaxine_mepesuccinate
Drugs.com:http://www.drugs.com/cdi/omacetaxine-injection.html
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| CASRN | 26833-87-4
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| prefixIRI | obo2:dinto_DB04865
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| SMILES | [H][C@]12[C@H](OC(=O)C(O)(CCCC(C)(C)O)CC(=O)OC)C(OC)=C[C@@]11CCCN1CCC1=CC3=C(OCO3)C=C21
|
| may interact with | |
| InChI | InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25+,28-,29?/m0/s1
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| DBBrand |
ceflatonin
synribo
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| subClassOf |
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| No notes to display |