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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB04573
http://purl.obolibrary.org/obo/dinto_DB04573
|
|---|---|
| Preferred Name | estriol |
| Synonyms |
C18H24O3
(1S,10R,11S,13R,14R,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,13,14-triol
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | estriol
|
|---|---|
| label | estriol
|
| DBSynonym |
(16?,17?)-estra-1,3,5(10)-triene-3,16,17-triol
16alpha-hydroxyestradiol
16?-hydroxyestradiol
16-alpha-hydroxyestradiol
oestriol
|
| ATCCode |
G03CA04
G03CC06
|
| Definition | A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes.
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| DBSalt | estriol tripropionate
|
| has pharmacological target | |
| induces | |
| activates | |
| inhibits | |
| type | |
| InChIKey | InChIKey=PROQIPRRNZUXQM-ZXXIGWHRSA-N
|
| Synonym | C18H24O3
(1S,10R,11S,13R,14R,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,13,14-triol
|
| xref |
PubChem Substance:46505881
ChemSpider:5553
PharmGKB:PA164769104
PDB:ESL
Wikipedia:http://en.wikipedia.org/wiki/Estriol
PubChem Compound:5756
ChEBI:27974
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| CASRN | 50-27-1
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| prefixIRI | obo2:dinto_DB04573
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| is transported by | |
| SMILES | [H][C@@]12C[C@@H](O)[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3
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| may interact with |
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| InChI | InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1
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| DBBrand | trimesta
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |