The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

oxitriptan

Synonyms

C11H12N2O3

(2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

ID

http://purl.obolibrary.org/obo/dinto_DB02959

ATCCode

N06AX01

CASRN

4350-09-8

DBBrand

levothym

DBSynonym

5-hydroxy-l-tryptophan

hydroxy-5 l-tryptophane

Definition

5-Hydroxytryptophan (5-HTP), also known as oxitriptan (INN), is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitters serotonin and melatonin from tryptophan. 5-HTP is sold over-the-counter in the United Kingdom, United States and Canada as a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, and is also marketed in many European countries for the indication of major depression under trade names like Cincofarm, Levothym, Levotonine, Oxyfan, Telesol, Tript-OH, and Triptum. Several double-blind placebo-controlled clinical trials have demonstrated the effectiveness of 5-HTP in the treatment of depression, though a lack of high quality studies has been noted. More and larger studies are needed to determine if 5-HTP is truly effective in treating depression.

InChI

InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1

InChIKey

InChIKey=LDCYZAJDBXYCGN-VIFPVBQESA-N

label

oxitriptan

prefixIRI

obo2:dinto_DB02959

prefLabel

oxitriptan

related with

http://purl.obolibrary.org/obo/dinto_0804

SMILES

N[C@@H](CC1=CNC2=C1C=C(O)C=C2)C(O)=O

Synonym

C11H12N2O3

(2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

xref

ChEBI:17780

PDB:HRP

Wikipedia:http://en.wikipedia.org/wiki/5-Hydroxytryptophan

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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