The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Id	http://purl.obolibrary.org/obo/dinto_DB01791 http://purl.obolibrary.org/obo/dinto_DB01791
Preferred Name	piclamilast
Synonyms	C18H18Cl2N2O3 3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide
Type	http://www.w3.org/2002/07/owl#Class

prefLabel	piclamilast
label	piclamilast
DBSynonym	rp 73-401
Definition	Piclamilast (RP-73,401), is a selective PDE4 inhibitor. It is comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as chronic obstructive pulmonary disease, bronchopulmonary dysplasia and asthma. It is a second generation compound that exhibits structural functionalities of the PDE4 inhibitors cilomilast and roflumilast. The structure for piclamilast was first elucidated in a 1995 European patent application.
type	http://www.w3.org/2002/07/owl#Class
InChIKey	InChIKey=RRRUXBQSQLKHEL-UHFFFAOYSA-N
Synonym	C18H18Cl2N2O3 3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide
xref	PubChem Compound:154575 ChemSpider:136184 BindingDB:14775 Wikipedia:http://en.wikipedia.org/wiki/Piclamilast PubChem Substance:46508612 PDB:PIL See more See less
CASRN	144035-83-6
prefixIRI	obo2:dinto_DB01791
related with	http://purl.obolibrary.org/obo/dinto_4063 http://purl.obolibrary.org/obo/dinto_3125 http://purl.obolibrary.org/obo/dinto_0074 http://purl.obolibrary.org/obo/dinto_2945
SMILES	COC1=CC=C(C=C1OC1CCCC1)C(=O)NC1=C(Cl)C=NC=C1Cl
InChI	InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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