The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Id	http://purl.obolibrary.org/obo/dinto_DB01597 http://purl.obolibrary.org/obo/dinto_DB01597
Preferred Name	cilastatin
Synonyms	(2Z)-7-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}-2-{[(1S)-2,2-dimethylcyclopropyl]formamido}hept-2-enoic acid C16H26N2O5S
Type	http://www.w3.org/2002/07/owl#Class

prefLabel	cilastatin
label	cilastatin
Definition	A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, imipenem, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4. [PubChem]
has pharmacological target	http://purl.obolibrary.org/obo/dinto_1639
inhibits	http://purl.obolibrary.org/obo/dinto_1975 http://purl.obolibrary.org/obo/dinto_1639 http://purl.obolibrary.org/obo/dinto_0520
type	http://www.w3.org/2002/07/owl#Class
InChIKey	InChIKey=DHSUYTOATWAVLW-WFVMDLQDSA-N
Synonym	(2Z)-7-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}-2-{[(1S)-2,2-dimethylcyclopropyl]formamido}hept-2-enoic acid C16H26N2O5S
xref	PubChem Compound:6435415 PharmGKB:PA448998 PubChem Substance:46505611 Wikipedia:http://en.wikipedia.org/wiki/Cilastatin ChEBI:3697 ChemSpider:4444109 PDB:CIL See more See less
CASRN	82009-34-5
prefixIRI	obo2:dinto_DB01597
SMILES	N[C@@H](CSCCCC\C=C(/NC(=O)[C@H]1CC1(C)C)C(=O)O)C(=O)O
may interact with	http://purl.obolibrary.org/obo/CHEBI_4031 http://purl.obolibrary.org/obo/CHEBI_63635
InChI	InChI=1S/C16H26N2O5S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23)/b12-6-/t10-,11+/m1/s1
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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