The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Id http://purl.obolibrary.org/obo/dinto_DB01583
http://purl.obolibrary.org/obo/dinto_DB01583
Preferred Name

liotrix
Synonyms
C30H21I7N2Na2O8
disodium (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate
Type http://www.w3.org/2002/07/owl#Class

All Properties

prefLabel
liotrix
label
liotrix
Definition
Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal secretion. It is now known that the thyroid gland secretes approximately ten times more T4 than T3 and that 80% of serum T3 is derived from deiodination of T4 in peripheral tissues. Administration of levothyroxine alone is sufficient for maintaining serum T4 and T3 levels in most patients and combination hormone replacement therapy generally offers no therapeutic advantage. In fact, administration of T3 may result in supratherapeutic levels of T3.
has pharmacological target
induces
activates
inhibits
type
InChIKey
InChIKey=LKYWLLWWYBVUPP-XOCLESOZSA-L
AHFScode
68:36.04
Synonym
C30H21I7N2Na2O8
disodium (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate
xref
PubChem Compound:71371
PubChem Substance:46506203
RxList:http://www.rxlist.com/cgi/generic/liot.htm
PharmGKB:PA164748036
Drugs.com:http://www.drugs.com/cdi/liotrix.html
ChemSpider:64467
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CASRN
8065-29-0
prefixIRI
obo2:dinto_DB01583
is transported by
related with
SMILES
[Na+].[Na+].N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C=C2)C(I)=C1)C([O-])=O.N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C([O-])=O
may interact with
InChI
InChI=1S/C15H11I4NO4.C15H12I3NO4.2Na/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);1-4,6,12,20H,5,19H2,(H,21,22);;/q;;2*+1/p-2/t2*12-;;/m00../s1
DBBrand
dithyron
novotiral
thyrolar
combithyrex
tyroplus
prothyrid
cynoplus
bitiron
levotrin
euthyral
euthroid
levotiroxina
novothyral
eutroid
tiroide amsa
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