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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB01436
http://purl.obolibrary.org/obo/dinto_DB01436
|
|---|---|
| Preferred Name | alfacalcidol |
| Synonyms |
C27H44O2
(1R,3S,5Z)-5-{2-[(1R,3aS,4E,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | alfacalcidol
|
|---|---|
| label | alfacalcidol
|
| DBSynonym |
1alpha-hydroxyvitamin d3
1alpha-hydroxycholecalciferol
1-hydroxycholecalciferol
|
| ATCCode | A11CC03
|
| Definition | Alfacalcidol is an active metabolite of Vitamin D, which performs important functions in regulation of the calcium balance and the bone metabolism. Alfacalcidol is Vitamin D-hormone analog which is activated by the enzyme 25-hydroxylase in the liver for systemic and in osteoblasts for local D-hormone actions. It possesses a unique pattern of pleiotropic effects on, e.g. gut, bone, pararthyroids, muscle and brain. Alfacalcidol is superior to plain vitamin D (cholecalciferol) because the final kidney activation of the latter is regulated by a negative feedback mechanism. (PMID:17438884,17668216)
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| has pharmacological target | |
| activates | |
| type | |
| InChIKey | InChIKey=OFHCOWSQAMBJIW-AVJTYSNKSA-N
|
| AHFScode | 88:16.00
|
| Synonym | C27H44O2
(1R,3S,5Z)-5-{2-[(1R,3aS,4E,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol
|
| xref |
PubChem Compound:5282181
ChemSpider:4445376
Drugs Product Database (DPD):474517
PharmGKB:PA164746469
PubChem Substance:46505115
|
| CASRN | 41294-56-8
|
| prefixIRI | obo2:dinto_DB01436
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| is substrate of | |
| related with | |
| SMILES | CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
|
| may interact with | |
| InChI | InChI=1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1
|
| DBBrand |
alsiodol
one alpha
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |