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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB01399
http://purl.obolibrary.org/obo/dinto_DB01399
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|---|---|
| Preferred Name | salsalate |
| Synonyms |
C14H10O5
2-[(2-hydroxyphenyl)carbonyloxy]benzoic acid
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | salsalate
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|---|---|
| label | salsalate
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| DBSynonym |
sasapyrine
salsalatum [inn-latin]
salicylsalicylic acid
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| ATCCode | N02BA06
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| Definition | Salsalate is a nonsteroidal anti-inflammatory agent for oral administration. Salsalate s mode of action as an anti-inflammatory and antirheumatic agent may be due to inhibition of synthesis and release of prostaglandins. The usefulness of salicylic acid, the active in vivo product of salsalate, in the treatment of arthritic disorders has been established. In contrast to aspirin, salsalate causes no greater fecal gastrointestinal blood loss than placebo. Salsalate is readily soluble in the small intestine where it is partially hydrolyzed to two molecules of salicylic acid. A significant portion of the parent compound is absorbed unchanged and undergoes rapid esterase hydrolysis in the body. The parent compound has an elimination half-life of about 1 hour. Salicylic acid (the active metabolite) biotransformation is saturated at anti-inflammatory doses of salsalate. Such capacity limited biotransformation results in an increase in the half-life of salicylic acid from 3.5 to 16 or more hours.
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| has effect |
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| has pharmacological target | |
| inhibits | |
| type | |
| InChIKey | InChIKey=WVYADZUPLLSGPU-UHFFFAOYSA-N
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| Synonym |
C14H10O5
2-[(2-hydroxyphenyl)carbonyloxy]benzoic acid
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| xref |
RxList:http://www.rxlist.com/cgi/generic/salsalate.htm
PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/dis1142.shtml
PubChem Substance:46506882
PubChem Compound:5161
ChemSpider:4977
Drugs.com:http://www.drugs.com/cdi/salsalate.html
PharmGKB:PA164745462
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| CASRN | 552-94-3
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| prefixIRI | obo2:dinto_DB01399
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| SMILES | OC(=O)C1=CC=CC=C1OC(=O)C1=CC=CC=C1O
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| may interact with |
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| InChI | InChI=1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)
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| DBBrand | disalcid
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |